14146-09-9

Basic information

• Product Name: BENZOFURAN, 2-METHYL-5-NITRO-
• Synonyms: BENZOFURAN, 2-METHYL-5-NITRO-;2-methyl-5-nitro-1-benzofuran;2-methyl-5-nitrobenzofuran;2-methyl-5-nitro-benzofuran
• CAS NO: 14146-09-9
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.16
• Mol File: 14146-09-9.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZOFURAN, 2-METHYL-5-NITRO-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOFURAN, 2-METHYL-5-NITRO-(14146-09-9)
• EPA Substance Registry System: BENZOFURAN, 2-METHYL-5-NITRO-(14146-09-9)

Safety Data

• Hazardous Substances Data: 14146-09-9(Hazardous Substances Data)

Upstream product

• 1568-66-7 1-allyloxy-4-nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 19182-96-8 2-allyl-4-nitrophenol 
• 79-41-4 poly(methacrylic acid) 
• 17061-85-7 1-nitro-4-(prop-2-ynyloxy)benzene 
• 350-46-9 4-Fluoronitrobenzene 
• 127-06-0 acetone oxime 
• 944677-72-9 2-(2-FORMYL-4-NITROPHENOXY)PROPANOIC ACID 
• 13680-03-0 propan-2-one O-(4-nitrophenyl)oxime 

Downstream Products

• 118679-18-8 2-bromomethyl-5-nitro-benzofuran 
• 26210-75-3 5-amino-2-methylbenzofuran 

Relevant articles and documents

Direct Synthesis of 2-Methylbenzofurans from Calcium Carbide and Salicylaldehyde p -Tosylhydrazones

A new methodology for the construction of methyl-substituted benzofuran rings from the reactions of calcium carbide with salicylaldehyde p-tosylhydrazones/2-hydroxyacetophenone p-tosylhydrazones is described. Various 2-methylbenzofurans and 2,3-dimethylbenzofurans could be obtained in satisfactory yield by using a cuprous chloride catalyst. The advantages of this protocol include the use of a readily available and easy-to-handle acetylene source and simple workup procedure.

Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C-H olefination of phenols

A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C-C bond formation and decarboxylation followed by the C-O cyclization pathway. This journal is

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b] furans and their BLT1 and/or BLT2 inhibitory activities

Several 2-alkylcarbamoyl-1-alkylvinylbenzo[b]furans were designed to find a selective leukotriene B4 (LTB4) receptor antagonist. 2-(2-Alkylcarbamoyl-1-alkylvinyl)benzo[b]furans having a substituent group at the 3-position, 4-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans having a substituent group at the 3-position, and 7-(2-alkylcarbamoyl-1-methylvinyl) benzo[b]furans and 3-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans were prepared and evaluated for LTB4 receptor (BLT1 and BLT 2) inhibitory activities. (E)-3-Amino-4-[2-[2-(3,4-dimethoxyphenyl) ethylcarbamoyl]-1-methylvinyl]benzo[b]furan ((E)-17c) showed potent and selective inhibitory activity for BLT2. On the other hand, (E)-7-(2-diethylcarbamoyl-1-methylvinyl)benzo[b]furan ((E)-27a) showed potent inhibitory activity for both BLT1 and BLT2. This journal is The Royal Society of Chemistry.