26210-75-3

Basic information

• Product Name: 2-METHYL-5-BENZOFURANAMINE
• Synonyms: 2-METHYL-BENZOFURAN-5-YLAMINE;2-METHYL-5-BENZOFURANAMINE;5-AMINO-2-METHYLBENZOFURAN;ASINEX-REAG BAS 08767887;CHEMBRDG-BB 4013733;CBI-BB ZERO/006154;TIMTEC-BB SBB010313;(2-methyl-1-benzofuran-5-yl)amine(SALTDATA: HCl)
• CAS NO: 26210-75-3
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 26210-75-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 282.9 °C at 760 mmHg
• Flash Point: 124.9 °C
• Appearance: /
• Density: 1.178 g/cm³
• Vapor Pressure: 0.00327mmHg at 25°C
• Refractive Index: 1.648
• PKA: 3.95±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-5-BENZOFURANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-BENZOFURANAMINE(26210-75-3)
• EPA Substance Registry System: 2-METHYL-5-BENZOFURANAMINE(26210-75-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 26210-75-3(Hazardous Substances Data)

Usage

Uses

2-Methyl-5-benzofuranamine is a benzofuranamide analogs which potentially exhibit low nanomolar inhibition of Cryptosporidium parvum IMP dehydrogenase (CpIMPDH).

InChI:InChI=1/C9H9NO/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5H,10H2,1H3

Upstream product

• 14146-09-9 2-methyl-5-nitrobenzofuran 
• 23968-38-9 N-(2-methylbenzofuran-5-yl)acetamide 
• 26557-77-7 N-(4-(prop-2-yn-1-yloxy)phenyl)acetamide 
• 103-90-2 4-acetaminophenol 

Downstream Products

• 288083-54-5 C₁₇H₁₃ClN₂O₂S 
• 1110660-25-7 C₁₇H₁₄N₂O₂S 

Relevant articles and documents

Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE

There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected from -S(=O)(=O)- and -C(=O)-, and Y is -NR3-; or X is selected from -S(=O)(=O)- and -S-, and Y is -C(R4)(R5)-; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety, Formula (II) wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1-C(=O)-NR3-L-R2; R1-S(=O)(=O)-C(R4)(R5)-L-R2; R1-S-C(R4)(R5)-L-R2; R1-NR3-S(=O)(=O)-L-R2; R1-NR3-C(=O)-L-R2; R1-C(R4)(R5)-S(=O)(=O)-L-R2; and R1-C(R4)(R5)-S-L-R2. These compounds are useful as 11β-hydroxysteriod dehydrogenase inhibitors in the treatment of i.a. diabetes.