1415144-53-4Relevant articles and documents
An iodocyclization approach to substituted 3-iodothiophenes
Gabriele, Bartolo,Mancuso, Raffaella,Salerno, Giuseppe,Larock, Richard C.
, p. 7640 - 7645 (2012/11/07)
A novel approach to 3-iodothiophenes by direct iodocyclization of alkynylthiol derivatives is presented. A variety of 1-mercapto-3-yn-2-ols 5 (readily available from alkynylation of the corresponding alpha-mercapto ketones or alpha-mercapto esters) were smoothly converted into the corresponding 3-iodothiophene derivatives 6 in good yields by reaction with molecular iodine in the presence of NaHCO3 at room temperature in MeCN as the solvent.