40789-98-8

Basic information

• Product Name: 3-Mercapto-2-butanone
• Synonyms: 3-mercapto-2-butanon;mercapto-3butanone-2;FEMA 3298;2-MERCAPTO-3-BUTANONE;3-MERCAPTO-2-BUTANONE;3-MERCAPTOBUTAN-2-ONE;3-MERCAPTOBUTANONE;3-MERCAPTO-2-BUTANONE 80+%
• CAS NO: 40789-98-8
• Molecular Formula: C₄H₈OS
• Molecular Weight: 104.17
• EINECS: 255-082-2
• Product Categories: Pharmaceutical Raw Materials;thiol Flavor;Alphabetical Listings;Flavors and Fragrances;M-N;Sulfides flavors
• Mol File: 40789-98-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 48-49 °C15 mm Hg(lit.)
• Flash Point: 117 °F
• Appearance: /
• Density: 1.035 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.25mmHg at 25°C
• Refractive Index: n20/D 1.4352
• Storage Temp.: Refrigerator
• PKA: 8.38±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-Mercapto-2-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Mercapto-2-butanone(40789-98-8)
• EPA Substance Registry System: 3-Mercapto-2-butanone(40789-98-8)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• RTECS: EL9050000
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 40789-98-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Preparation

From 2,4,5-trimethyl-2-ethyl-3-thiazoline with butyl and hydrolysis; from oxo-compound with sulfur or polysulfides and ammonia at room temperature.

General Description

3-Mercapto-2-butanone is a sulfur-containing flavor compound mainly found in meat and meat products. It is formed by the Maillard reaction between sugars and cysteine or thiamin, which are known precursors for meat-like flavorings.

Biochem/physiol Actions

Taste at 0.3-1.0 ppm

InChI:InChI=1/C4H8OS/c1-3(5)4(2)6/h4,6H,1-2H3

Upstream product

• 4091-39-8 3-chloro-2-butanone 
• 87602-19-5 2,2,4,4-Tetramethyl-[1,3]oxathiolan-5-one 
• 431-03-8 dimethylglyoxal 
• 28588-74-1 2-methylfuran-3-thiol 
• 513-86-0 3-hydroxy-2-butanon 
• 61323-21-5 3-acetylthio-2-butanone 
• 52-90-4 L-Cysteine 
• 1262683-58-8 [13C₅]xylose 
• 59-43-8 vitamin B₁ 
• 58-86-6 D-xylose 

Downstream Products

• 78-93-3 butanone 
• 82694-43-7 (4,5-dimethyl-3-phenyl-3H-thiazol-2-ylidene)-phenyl-amine 
• 56157-60-9 2-(benzylthio)-4,5-dimethylthiazole 
• 92802-34-1 3-(2-Oxo-2-phenyl-ethylsulfanyl)-butan-2-one 
• 2861-48-5 butane-2,3-dione-bis-phenylhydrazone 
• 1158836-88-4 ethyl 2-(diphenylphosphoryl)-1-methyl-2-[(1-methyl-2-oxopropyl)sulfanyl]ethylidene-1-hydrazinecarboxylate 
• 203636-17-3 5-(4-methoxyphenyl)-3-methylpentan-2-one 
• 175217-20-6 silthiofam 
• 14559-13-8 methyl 4,5-dimethylthiophene-3-carboxylate 
• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 1415144-53-4 1-(4-bromophenyl)-4-mercapto-3-methylpent-1-yn-3-ol 
• 1403459-91-5 4-mercapto-3-methyl-1-phenylpent-1-yn-3-ol 
• 943332-73-8 2-(3-chlorophenyl)-4,5-dimethyl-4-hydroxy-3-[(3-pyridyl)carbonyl]-4,5-dihydrothiophene 
• 112177-97-6 4,5-Dimethyl-2-phenyl-2,5-dihydro-thiophene-3-carboxylic acid methyl ester 

Relevant articles and documents

Effect of pH on the maillard reaction of [C]xylose, cystein, and thiamin

The influence of different pH values, ranging from 4.0 to 7.0, on the formation of sulfur volatiles in the Maillard reaction was studied using a model system with [13C5]xylose, cysteine, and thiamin. The use of 13C-labeled xylose allowed, by analysis of the mass spectra, volatiles that incorporated xylose carbons in the molecule from other carbon sources to be discerned. For 2-furaldehyde and 2-furfurylthiol, which were favored at low pH, the labeling experiments clearly indicated that xylose was the exclusive carbon source. On the other hand, xylose was virtually not involved in the formation of 3-mercapto-2-butanone, 4,5-dihydro-2-methyl-3- furanthiol, and 5-(2-hydroxyethyl)-4-methylthiazole, which apparently stemmed from thiamin degradation. Both xylose and thiamin seemed to significantly contribute to the formation of 2-methyl-3-furanthiol, 3-mercapto-2-pentanone, and 2-mercapto-3-pentanone, and therefore different formation pathways must exist for each of these molecules. In general, the pH determined strongly which volatiles were formed, and to what extent. However, the relative contribution of xylose to the C-skeleton of a particular compound changed only slightly within the investigated pH range, when both xylose and thiamin were involved in the formation.

A novel and expeditious approach to thiophene-3-carboxylates

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Some Novel Meatlike Aroma Compounds from the Reactions of Alkanediones with Hydrogen Sulfide and Furanthiols

The products of reactions of hydrogen sulfide with 2,3-butanedione and with 2,3-pentanedione in dilute ethanolic solution were analyzed by GC-MS and GC-odor port analysis.Components were also collected from the GC column and analyzed by 1H NMR.Mercaptoketones were formed which readily oxidized to the corresponding disulfides with traces of mono- and trisulfides.When 2-methyl-3-furanthiol or 2-furylmethanethiol was added to the reaction mixtures, a series of disulfides containing alkanone, 2-methyl-3-furyl and 2-furanmethyl moieties were formed.Some of these compounds have been found recently in the volatiles of cooked meat and in meatlike model systems.GC-odor port evaluation of the components of the reaction systems showed that disulfides containing the 2-methyl-3-furyl group had meaty aromas, whereas those without this group were sulfurous or onion-like in character.Keywords: Aroma; meat; mercaptoketones; disulfides