1415407-08-7Relevant articles and documents
Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists
Chen, Wei-Dong,Fu, Yajie,Hou, Ruifang,Li, Yunfu,Wang, Chenwei,Wang, Jie,Wang, Le,Wang, Yan-Dong,Yang, Dongbin,Zhao, Shizhen,Zheng, Shaowei
, p. 3618 - 3629 (2022/02/11)
TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated