1415931-35-9

Basic information

• Product Name: C₁₆H₁₂ClNSe
• Synonyms: C₁₆H₁₂ClNSe
• CAS NO: 1415931-35-9
• Molecular Weight: 332.691
• Mol File: 1415931-35-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₂ClNSe(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₂ClNSe(1415931-35-9)
• EPA Substance Registry System: C₁₆H₁₂ClNSe(1415931-35-9)

Safety Data

• Hazardous Substances Data: 1415931-35-9(Hazardous Substances Data)

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 69447-36-5 bis(2-methylphenyl) diselenide 

Relevant articles and documents

A simple method for the synthesis of 4-arylselanyl-7-chloroquinolines used as in vitro acetylcholinesterase inhibitors and in vivo memory improvement

We described here an alternative method for the synthesis of 4-arylselanyl-7-chloroquinolines through reactions of 4,7-dichloroquinoline with organylselenols, generated in situ by the reaction of diorganyl diselenides with H3PO2 (50?wt% in H2O). These reactions proceeded efficiently at 60?°C under N2 atmosphere and are suitable to a range of diorganyl diselenides containing electron-donating and electron-withdrawing groups, affording the corresponding 4-aryl-7-chloroquinolines in high yields. The synthesized compounds were screened for their in vitro acetylcholinesterase (AChE) activity and our results demonstrated that the 7-chloro-4-[(4-fluorophenyl)selanyl]quinoline inhibited the AChE activity and improved memory in mice, making this compound is a potential therapeutic agent for the treatment of Alzheimer disease and other neurodegenerative disorders.