141595-75-7Relevant articles and documents
Peptidyl calcium channel blockers
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, (2008/06/13)
The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
Aniline derivatives as calcium channel blockers
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, (2008/06/13)
The present invention provides compounds that block calcium channels having formula (I). The present invention also provides methods of using the compounds of formula (I) to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of formula (I).
Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties
Hu, Lain-Yen,Ryder, Todd R.,Rafferty, Michael F.,Feng, M. Rose,Lotarski, Susan M.,Rock, David M.,Sinz, Michael,Stoehr, Sally J.,Taylor, Charles P.,Weber, Mark L.,Bowersox, S. Scott,Miljanich, George P.,Millerman, Elizabeth,Wang, Yong-Xiang,Szoke, Balazs G.
, p. 4239 - 4249 (2007/10/03)
In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is described. N-Type VSCC blockers, such as ziconotide, have shown utility in several models of str