1421708-62-4

Basic information

• Product Name: C₃₇H₄₀O₁₂
• CAS NO: 1421708-62-4
• Molecular Weight: 676.717
• Mol File: 1421708-62-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₀O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₀O₁₂(1421708-62-4)
• EPA Substance Registry System: C₃₇H₄₀O₁₂(1421708-62-4)

Safety Data

• Hazardous Substances Data: 1421708-62-4(Hazardous Substances Data)

Upstream product

• 1243391-44-7 3-(cyclopropylmethoxy)-4-hydroxybenzoic acid 
• 1392191-29-5 methyl 3-(cyclopropylmethoxy)-4-iodobenzoate 
• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 58123-77-6 3-hydroxy-4-iodobenzoic acid 
• 848574-60-7 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester 
• 75-45-6 Chlorodifluoromethane 

Relevant articles and documents

A new route to Roflumilast via copper-catalyzed hydroxylation

A new route to Roflumilast, a selective phosphodiesterase type 4 (PDE 4) inhibitor, is described. The synthetic procedure starts from 4-hydroxy-3-iodobenzoic acid to access the key intermediate 3- (cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid via copper-catalyzed hydroxylation and utilizes amide coupling to accomplish the synthesis of Roflumilast in 80% overall yield. Georg Thieme Verlag KG Stuttgart · New York.