1424432-36-9

Basic information

• Product Name: C₂₅H₃₂N₆O₂
• Synonyms: C₂₅H₃₂N₆O₂
• CAS NO: 1424432-36-9
• Molecular Weight: 448.568
• Mol File: 1424432-36-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₂N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₂N₆O₂(1424432-36-9)
• EPA Substance Registry System: C₂₅H₃₂N₆O₂(1424432-36-9)

Safety Data

• Hazardous Substances Data: 1424432-36-9(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 58584-92-2 2-amino-6-chloronicotinic acid 
• 938443-23-3 7-chloro-2-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidine 
• 938443-21-1 4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)morpholine 
• 938443-20-0 2,4,7-trichloropyrido[2,3-d]pyrimidine 
• 938443-19-7 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 64321-24-0 2-amino-6-chloro-pyridine-3-carboxamide 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 

Relevant articles and documents

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

The optimization of a potent and highly selective series of dual mTORC1 and mTORC2 inhibitors is described. An initial focus on improving cellular potency whilst maintaining or improving other key parameters, such as aqueous solubility and margins over hERG IC50, led to the discovery of the clinical candidate AZD8055 (14). Further optimization, particularly aimed at reducing the rate of metabolism in human hepatocyte incubations, resulted in the discovery of the clinical candidate AZD2014 (21).