938443-23-3 Usage
General Description
The chemical compound Pyrido[2,3-d]pyriMidine, 7-chloro-2-[(2R,6S)-2,6-diMethyl-4-Morpholinyl]-4-(4-Morpholinyl)-, rel- is a heterocyclic compound with a pyridine and pyrimidine ring structure. It contains a chlorine atom and two morpholine groups, along with two methyl groups in a stereo-specific configuration. Pyrido[2,3-d]pyriMidine, 7-chloro-2-[(2R,6S)-2,6-diMethyl-4-Morpholinyl]-4-(4-Morpholinyl)-, rel- is likely to exhibit bioactive properties due to its complex structure and potentially interacting moieties. Further research is needed to determine its specific biological activities and potential applications in the fields of pharmaceuticals or materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 938443-23-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,8,4,4 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 938443-23:
(8*9)+(7*3)+(6*8)+(5*4)+(4*4)+(3*3)+(2*2)+(1*3)=193
193 % 10 = 3
So 938443-23-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H22ClN5O2/c1-11-9-23(10-12(2)25-11)17-20-15-13(3-4-14(18)19-15)16(21-17)22-5-7-24-8-6-22/h3-4,11-12H,5-10H2,1-2H3/t11-,12+
938443-23-3Relevant articles and documents
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014
Pike, Kurt G.,Malagu, Karine,Hummersone, Marc G.,Menear, Keith A.,Duggan, Heather M.E.,Gomez, Sylvie,Martin, Niall M.B.,Ruston, Linette,Pass, Sarah L.,Pass, Martin
, p. 1212 - 1216 (2013/03/14)
The optimization of a potent and highly selective series of dual mTORC1 and mTORC2 inhibitors is described. An initial focus on improving cellular potency whilst maintaining or improving other key parameters, such as aqueous solubility and margins over hERG IC50, led to the discovery of the clinical candidate AZD8055 (14). Further optimization, particularly aimed at reducing the rate of metabolism in human hepatocyte incubations, resulted in the discovery of the clinical candidate AZD2014 (21).
2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS
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Page/Page column 103-104, (2008/06/13)
There is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula (1), and the use of a compound of Formula (1) as a medicament and in the treatment of cancer