1424614-82-3

Basic information

• Product Name: (Z)-1-cyclohexyloxy-1-(trimethylsiloxy)propene
• CAS NO: 1424614-82-3
• Molecular Weight: 228.407
• Mol File: 1424614-82-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-1-cyclohexyloxy-1-(trimethylsiloxy)propene(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-cyclohexyloxy-1-(trimethylsiloxy)propene(1424614-82-3)
• EPA Substance Registry System: (Z)-1-cyclohexyloxy-1-(trimethylsiloxy)propene(1424614-82-3)

Safety Data

• Hazardous Substances Data: 1424614-82-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 6222-35-1 cyclohexyl propionate 

Relevant articles and documents

An enantioselective, intermolecular α-arylation of ester enolates to form tertiary stereocenters

In transition-metal catalyzed, asymmetric α-arylation of carbonyl compounds, formation of tertiary centers with high enantioselectivity is a longstanding problem, due to easy enolization of the monoarylation products. Herein, we report such examples using a palladium catalyst supported by a new, (R)-H8-BINOL-derived monophosphine. Silyl ketene acetals, together with a weakly basic activator, were used as equivalents of ester anions, and they reacted smoothly with aryl triflates in excellent enantiomeric excess (ee). The usefulness of the reaction was demonstrated in a gram-scale synthesis of (S)-Naproxen in 92% ee.