6222-35-1

Basic information

• Product Name: CYCLOHEXYL PROPIONATE
• Synonyms: PROPIONIC ACID CYCLOHEXYL ESTER;Cyclohexyl n-propionate;Cyclohexyl propanoate;Propanoic acid, cyclohexyl ester;propanoicacid,cyclohexylester;FEMA 2345;FEMA 2354;CYCLOHEXYL PROPIONATE
• CAS NO: 6222-35-1
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22
• EINECS: 228-303-5
• Product Categories: Alphabetical Listings;C-D;Flavors and Fragrances
• Mol File: 6222-35-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 72-73 °C10 mm Hg(lit.)
• Flash Point: 154 °F
• Appearance: /
• Density: 0.954 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.385mmHg at 25°C
• Refractive Index: n20/D 1.441(lit.)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol (Slightly)
• Stability: Volatile
• CAS DataBase Reference: CYCLOHEXYL PROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYL PROPIONATE(6222-35-1)
• EPA Substance Registry System: CYCLOHEXYL PROPIONATE(6222-35-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6222-35-1(Hazardous Substances Data)

Usage

Chemical Properties

Cyclohexyl propionate has an apple- and banana-like aroma.

Uses

Cyclohexyl Propionate is a synthetic flavoring agent that is a sta- ble, colorless liquid of fruity odor. it is stored in glass or tin contain- ers. it is used in fruit flavors such as pineapple with applications in beverages, candy, ice cream, and baked goods at approximately 3 ppm.

Preparation

By direct esterification of the alcohol with the acid in the presence of concentrated sulfuric acid or in the presence of benzene.

Taste threshold values

Taste characteristics at 30 ppm; sweet, fruity, banana with green waxy nuance.

InChI:InChI=1/C9H16O2/c1-2-9(10)11-8-6-4-3-5-7-8/h8H,2-7H2,1H3

Upstream product

• 637-27-4 phenyl propionate 
• 802294-64-0 propionic acid 
• 110-83-8 cyclohexene 
• 123-62-6 propionic acid anhydride 
• 108-93-0 cyclohexanol 
• 79-03-8 propionyl chloride 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 105-37-3 Ethyl propionate 
• 107-12-0 propiononitrile 

Downstream Products

• 22733-94-4 benzyl cyclohexanecarboxylate 
• 802294-64-0 propionic acid 
• 108-93-0 cyclohexanol 
• 110-82-7 cyclohexane 
• 1239020-67-7 (1E)-1-cyclohexyloxy-1-(trimethylsiloxy)propene 
• 1424614-82-3 (Z)-1-cyclohexyloxy-1-(trimethylsiloxy)propene 

Relevant articles and documents

Method for preparing propionate by ester alcohol exchange

The invention discloses a method for preparing propionate by ester alcohol exchange, and relates to a method for preparing propionate. According to the invention, the method for synthesizing propionate by ester alcohol exchange of methyl propionate and various alcohols (including monohydric alcohols such as ethanol, propanol, butanol, tert-butanol, isopropanol, cyclohexanol, allyl alcohol and thelike, dihydric alcohols such as 1,3-propylene glycol and the like, glycerol and the like) is adopted, and methyl propionate and the alcohols are used as raw materials to carry out a reaction under catalysis of alkaline ionic liquid, soluble strong alkali or solid alkali to prepare higher propionate and methanol. According to the method, the synthetic route is short, and the reaction product is taken out through azeotropic extraction of the methyl propionate and methanol, so that the reaction is more thorough, and the target product is directly obtained by one step. The product obtained by thereaction only contains propionate and methanol, the whole reaction process is concise and efficient and is free of pollution, no byproducts are generated, and great significance is achieved for large-scale and low-cost production of propionate.

Efficient Palladium-Catalyzed Alkoxycarbonylation of Bulk Industrial Olefins Using Ferrocenyl Phosphine Ligands

The development of ligands plays a key role and provides important innovations in homogeneous catalysis. In this context, we report a novel class of ferrocenyl phosphines for the alkoxycarbonylation of industrially important alkenes. A basic feature of our ligands is the combination of sterically hindered and amphoteric moieties on the P atoms, which leads to improved activity and productivity for alkoxycarbonylation reactions compared to the current industrial state-of-the-art ligand 1,2-bis((di-tert-butylphosphino)methyl)benzene). Advantageously, palladium catalysts with these novel ligands also enable such transformations without additional acid under milder reaction conditions. The practicability of the optimized ligand was demonstrated by preparation on >10 g scale and its use in palladium-catalyzed carbonylations on kilogram scale.

Tris(pentafluorophenyl)borane catalyzed acylation of alcohols, phenols, amines, and thiophenols under solvent-free condition

The acylation of alcohols, phenols, amines, and thiophenols was accomplished with 0.5 mol % of tris(pentafluorophenyl)borane [B(C 6F5)3] at ambient temperature under solvent-free condition. Major advantages of this method include high yield, short reaction time, simple procedure, compatibility with sensitive protecting groups as well as other functional groups, absence of racemization of optical active compounds, and epimerization of sugars.