1425485-72-8 Usage
Description
DBCO-C6-Acid, an analog of DBCO-Acid, features an extended 6-carbon atom spacer arm that enhances its derivatization efficiency, stability of the yielded conjugates, and solubility in organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. It is widely utilized in copper-free Click Chemistry reactions.
Uses
Used in Chemical Synthesis:
DBCO-C6-Acid is used as a reagent for the preparation of N,N-dialkylhydroxylamines, which are essential in various chemical and pharmaceutical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DBCO-C6-Acid is used as a key component in the synthesis of drug conjugates, taking advantage of its improved derivatization efficiency and stability.
Used in Research and Development:
For research purposes, DBCO-C6-Acid is employed in the development of new chemical entities and the study of copper-free Click Chemistry reactions, contributing to the advancement of chemical and biological research.
Used in Material Science:
In material science, DBCO-C6-Acid can be utilized in the creation of novel materials with specific properties, leveraging its enhanced solubility and reactivity in organic solvents.
Check Digit Verification of cas no
The CAS Registry Mumber 1425485-72-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,5,4,8 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1425485-72:
(9*1)+(8*4)+(7*2)+(6*5)+(5*4)+(4*8)+(3*5)+(2*7)+(1*2)=168
168 % 10 = 8
So 1425485-72-8 is a valid CAS Registry Number.
1425485-72-8Relevant articles and documents
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
Ao, Jiwei,Huang, He,Huang, Wei,Jiang, Bofeng,Liu, Junjie,Ren, Xuelian,Shi, Wei,Tang, Feng,Tang, Yubo,Yang, Weibo,Yu, Qun
, p. 19940 - 19944 (2020)
Strain-promoted azide–alkyne cycloaddition using dibenzoazacyclooctyne (DBCO) is widely applied in copper-free bioorthogonal reactions. Reported here is the efficient acid-promoted rearrangement and silver-catalyzed amidation of DBCO, which alters its click reactivity robustly. In the switched click reaction, DBCO, as a caged acylation reagent, enables rapid peptide/protein modification after decaging facilitated by silver catalysts, rendering site-specific conjugation of an IgG antibody by a Fc-targeting peptide.
