142589-42-2

Basic information

• Product Name: (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester
• Synonyms: (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester
• CAS NO: 142589-42-2
• Molecular Weight: 438.48
• Mol File: 142589-42-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester(142589-42-2)
• EPA Substance Registry System: (S)-N-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-hydroxy-(S)-norleucine methyl ester(142589-42-2)

Safety Data

• Hazardous Substances Data: 142589-42-2(Hazardous Substances Data)

Upstream product

• 167090-40-6 (S)-2-amino-6-hydroxy-hexanoic acid methyl ester 
• 32150-91-7 phthaloyl-L-phenylalanyl chloride 
• 5458-06-0 5-(4-hydroxybutyl)hydantoin 
• 110-87-2 3,4-dihydro-2H-pyran 
• 6033-32-5 (S)-2-amino-6-hydroxyhexanoic acid 
• 16509-61-8 (R)-2-amino-6-hydroxy-hexanoic acid 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 213176-15-9 (S)-(-)-tert-butyl-2-<(tert-butoxycarbonyl)amino>-6-hydroxyhexanoate 
• 97347-28-9 Boc-Lys(Boc)-Otert-Bu 
• 97347-40-5 N^α,N^ca-diBoc-L-2-aminoadipamic acid tert-butyl ester 
• 63-91-2 L-phenylalanine 
• 85-44-9 phthalic anhydride 

Downstream Products

• 142589-43-3 (S)-2-[(S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-6-oxo-hexanoic acid methyl ester 
• 111581-88-5 [S(R*,R*)]-1-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridinecarboxylicacid, methyl ester 

Relevant articles and documents

N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors

N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p— R1is H or COR2where R2is alkyl, aryl-(CH2)p—, cycloheteroalkyl-(CH2)p—, heteroaryl-(CH2)p—, alkoxy or cycloalkyl-(CH2)p—, p is 0 to 8, and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic. The above compounds are useful in treating hypertension congestive heart failure, renal failure, and hepatic cirrhosis.

A novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives

Oxidation of carbamates with catalytic RuO4, generated from RuO2 and NaBrO3, provides the corresponding acyl carbamates, which can be reduced with NaBH4 to provide alcohols. Application of this methodology to L-lysine provides (S)-6-hydroxynorleucine derivatives.