14267-17-5Relevant articles and documents
Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase
Al-Janabi, Ahmed S. M.,Saleh, Abdulrahman M.,Hatshan, Mohammad R.
, p. 1104 - 1115 (2021/02/20)
Ten transition metal dithiocarbamate (DTC)complexes of the type [M(κ2-Et2DT)2] (1–5), and [M(κ2-PyDT)2] (6–10) (where M?=?Co, Ni, Cu, Pd, and Pt; Et2DT?=?diethyl dithiocarbamate; PyDT?=?pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species. The results showed the Pt-dithiocarbamate complexes are more active against all the tested bacteria than the Pd-dithiocarbamate complex. The dithiocarbamate complexes displayed the maximum inhibition zone against E. coli bacteria, whereas the lowest activity of the dithiocarbamate against Salmonella typhimurium bacteria. The cytotoxicity of the Pd(II) and Pt(II) complexes was screened against the MCF-7 breast cancer cell line and the complexes showed moderate activity compared with the cis-platin. The results indicated that the MCF7 cells treated with 500?μgml of ligands and Pd(II) and Pt(II) complexes after 24 hr exposure showed intercellular space and dead cells. Finally, molecular docking studies were carried out to examine the binding mode of the synthesized compounds against the proposed target; SARS COV2 RNA-dependent RNA polymerase.
Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)-Dithiocarbamate Phenanthroline Complex
Flamme, Marie,Cressey, Paul B.,Lu, Chunxin,Bruno, Peter M.,Eskandari, Arvin,Hemann, Michael T.,Hogarth, Graeme,Suntharalingam, Kogularamanan
, p. 9674 - 9682 (2017/07/22)
The cytotoxic properties of a series of nickel(II)-dithiocarbamate phenanthroline complexes is reported. The complexes 1–6 kill bulk cancer cells and cancer stem cells (CSCs) with micromolar potency. Two of the complexes, 2 and 6, kill twice as many breast cancer stem cell (CSC)-enriched HMLER-shEcad cells as compared to breast CSC-depleted HMLER cells. Complex 2 inhibits mammosphere formation to a similar extent as salinomycin (a CSC-specific toxin). Detailed mechanistic studies suggest that 2 induces CSC death by necroptosis, a programmed form of necrosis. Specifically, 2 triggers MLKL phosphorylation, oligomerization, and translocation to the cell membrane. Additionally, 2 induces necrosome-mediated propidium iodide (PI) uptake and mitochondrial membrane depolarisation, as well as morphological changes consistent with necroptotosis. Strikingly, 2 does not evoke necroptosis by intracellular reactive oxygen species (ROS) production or poly(ADP) ribose polymerase (PARP-1) activation.
Synthesis, crystal structures, magnetic properties and photoconductivity of C60 and C70 complexes with metal dialkyldithiocarbamates M(R2dtc)x, where M = CuII, CuI, AgI, ZnII, CdII, HgII, Mn II, NiII, and PtII; R = Me, Et, and nPr
Konarev, Dmitri V.,Kovalevsky, Andrey Y.,Khasanov, Salavat S.,Saito, Gunzi,Lopatin, Dmitri V.,Umrikhin, Alexey V.,Otsuka, Akihiro,Lyubovskaya, Rimma N.
, p. 1881 - 1895 (2007/10/03)
New complexes of fullerenes C60 and C70 with metal dialkyldithiocarbamates, [M(R2dtc)x]·[C 60(70)]·[Solvent], R = Et [M = CuII (C60, 1; C70, 2), CuI (C60, 3; C70, 4), AgI (C60, 5), ZnII (C 60, 6), CdII (C60, 7; C70, 8), HgII (C60, 9), MnII (C70, 10)], R = Et and Me [M = CuII (C60, 11), and ZnII (C 60, 12)], and R = nPr [M = CuII (C60, 13), NiII (C60, 14), and PtII (C60, 15)] were obtained. M(R2dtc)x efficiently cocrystallized with fullerene molecules as tetrahedral monomers (6, 12), dimers (1, 7, 11), and tetramers (3, 4). Fullerene molecules form closely packed hexagonal and square layers in 1, 7, and 11, hexagonal and tetragonal 3D structures in 6 and 12, and island motifs in 3 and 4. Complexes 1-15 have a neutral ground state. However, the formation of the complexes with fullerenes changes the environment of paramagnetic CuII and MnII. The EPR spectra of 1, 2, 11, and 13 are essentially modified relative to those of pristine Cu(R 2dtc)2 because of a weak coordination of CuII to fullerene and a flattening of the central (NCS2)2Cu fragments. Complex 10 shows a spectrum exhibiting features from 50 to 600 mT and manifests strong antiferromagnetic coupling of spins with a Weiss temperature of -96 K and the maximum of magnetic susceptibility at 46 K. Such magnetic behavior can be explained by the formation of [Mn(Et2dtc) 2]2 dimers in 10. The illumination of the crystals of 1, 2, and 7 by white light results in up to a 103 increase in photocurrent. The photoconductivity spectra have maxima at 470, 450-650, and 660 nm for 1, 2, and 7, respectively. Photogeneration of free charge carriers is realized by photoexcitation of Cu(Et2dtc)2 in 1 and 2, and by charge transfer from Cd(Et2dtc)2 to C60 molecules in 7. The decrease of photocurrent in 1 and 7 in a weak magnetic field with B0 0.5 T was found. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
