14271-73-9 Usage
Description
4-METHYLBENZOYL CYANIDE, also known as p-tolual cyanide, is an organic compound with the chemical formula C9H7NO. It is a colorless to pale yellow liquid with a characteristic odor. 4-METHYLBENZOYL CYANIDE is an important intermediate in the synthesis of various organic compounds and pharmaceuticals due to its unique chemical structure.
Uses
Used in Pharmaceutical Industry:
4-METHYLBENZOYL CYANIDE is used as a reactant for the synthesis of a muscarinic acetylcholine receptor (mAChR) modulator. It plays a crucial role in the development of drugs targeting the central nervous system, particularly those aimed at treating conditions such as Alzheimer's disease, schizophrenia, and other cognitive disorders.
In the synthesis process, 4-METHYLBENZOYL CYANIDE serves as a key building block, providing the necessary structural framework for the final mAChR modulator. Its reactivity and functional groups enable the formation of various chemical bonds, allowing for the creation of complex molecules with specific biological activities.
The use of 4-METHYLBENZOYL CYANIDE in the pharmaceutical industry highlights its importance as a versatile and valuable chemical intermediate. Its application in the synthesis of mAChR modulators demonstrates its potential in contributing to the development of novel therapeutic agents for a range of neurological and psychiatric conditions.
Synthesis Reference(s)
Tetrahedron Letters, 26, p. 925, 1985 DOI: 10.1016/S0040-4039(00)61966-4Synthesis, p. 637, 1983 DOI: 10.1055/s-1983-30454
Check Digit Verification of cas no
The CAS Registry Mumber 14271-73-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,7 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 14271-73:
(7*1)+(6*4)+(5*2)+(4*7)+(3*1)+(2*7)+(1*3)=89
89 % 10 = 9
So 14271-73-9 is a valid CAS Registry Number.
14271-73-9Relevant articles and documents
Efficient Synthesis of Aroyl Cyanides and Hetero Analogs from Aroyl Chlorides and Potassium Cyanide
Tanaka, Masato,Koyanagi, Masayuki
, p. 973 - 974 (1981)
-
Anomalous Reaction of Arylmalononitriles with Nitric Acid. Para-Directing Nature of Dicyanomethyl Group and a Through-Ring Nitro/aci-Nitro Tautomerism of 4-Nitrophenylmalononitrile
Suzuki, Hitomi,Koide, Hideki,Ogawa, Takuji
, p. 501 - 504 (1988)
Phenylmalononitrile reacts with nitric acid in dichloromethane at room temperature to afford 1,2-bis(4-nitrophenyl)-1,1,2,2-tetracyanoethane as an initial product, which readily suffers oxidative cleavage to give 4-nitrobenzoyl cyanide.Contrary to common
Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source
Lu, Hao,Li, Zheng
supporting information, p. 4474 - 4482 (2019/08/20)
Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones by the reactions of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides is described. The salient features of this protocol are the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance, and simple work-up procedure. (Figure presented.).
Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes
Li, Meina,Kong, Duanyang,Zi, Guofu,Hou, Guohua
, p. 680 - 687 (2017/04/26)
A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.
