65205-55-2

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(4-methoxyphenyl)-5-(4-methylphenyl)-
• CAS NO: 65205-55-2
• Molecular Formula: C16H14N2O2
• Molecular Weight: 266.299
• Mol File: 65205-55-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(4-methoxyphenyl)-5-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(4-methoxyphenyl)-5-(4-methylphenyl)-(65205-55-2)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(4-methoxyphenyl)-5-(4-methylphenyl)-(65205-55-2)

Safety Data

• Hazardous Substances Data: 65205-55-2(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 5373-87-5 (Z)-N'-hydroxy-4-methoxybenzenecarboximidamide 
• 14271-73-9 4-methylbenzoyl cyanide 
• 5373-87-5 4-methoxybenzamidoxime 
• 874-90-8 4-methoxybenzonitrile 
• 16013-13-1 3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 72093-98-2 3'-(4-methoxy-phenyl)-5-phenyl-3,5'-(4,4'-trans-ethene-1,2-diyl-diphenyl)-bis-[1,2,4]oxadiazole 
• 65204-78-6 5-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65204-93-5 5-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65204-84-4 5-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65204-97-9 5-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 65965-69-7 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-styryl}-phenyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 65204-87-7 3-(4-methoxy-phenyl)-5-{4-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 65204-72-0 3-(4-methoxy-phenyl)-5-{4-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 71944-56-4 3-(4-methoxy-phenyl)-5-{4-[4-(1-phenyl-1H-pyrazol-3-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 72093-88-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72093-87-9 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-5-methyl-benzooxazole 
• 64893-30-7 2-(4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-benzooxazole 
• 72094-17-8 5-(4-{2-chloro-4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-(4-methoxy-phenyl)-[1,2,4]oxadiazole 
• 72094-27-0 2-(3-chloro-4-{4-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-naphtho[1,2-d][1,2,3]triazole 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Microwave assisted synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from substituted amidoximes and benzoyl cyanides

We report herein the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and substituted or unsubstituted benzoyl cyanides under microwave irradiation. Substituted or unsubstituted O-carboxyphenyl amidoxime is a key intermediate of this alternative method developed for the synthesis of these heterocycles. These reactions employ simple synthetic protocols devoid of lengthy purification procedures and proceed with good yield.