1427180-45-7

Basic information

• Product Name: (3-bromophenyl)formamido 2,2-dimethylpropanoate
• Synonyms: (3-bromophenyl)formamido 2,2-dimethylpropanoate
• CAS NO: 1427180-45-7
• Molecular Weight: 300.152
• Mol File: 1427180-45-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3-bromophenyl)formamido 2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromophenyl)formamido 2,2-dimethylpropanoate(1427180-45-7)
• EPA Substance Registry System: (3-bromophenyl)formamido 2,2-dimethylpropanoate(1427180-45-7)

Safety Data

• Hazardous Substances Data: 1427180-45-7(Hazardous Substances Data)

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 2593-28-4 3-bromo-N-hydroxybenzamide 
• 3282-30-2 pivaloyl chloride 
• 585-76-2 m-bromobenzoic acid 
• 35657-35-3 O-Pivaloylhydroxylamine hydrochloride 
• 1293990-73-4 O-pivaloylhydroxylamine trifluoromethanesulfonate salt 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 190777-77-6 5-bromo-1,2-dihydroisoquinolin-1-one 
• 223671-15-6 7-bromo-1(2H)-isoquinolone 

Relevant articles and documents

Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

This study describes general synthesis aspects of fragments for FBDD, as illustrated by the dihydroisoquinolones 1-3. Previous Rh(iii) methodology is extended to incorporate amines, heteroatoms (N and S), and substituents (halogen, ester) as potential binding groups and/or synthetic growth points for fragment-to-lead elaboration.

Complementary regioselectivity in Rh(III)-catalyzed insertions of potassium vinyltrifluoroborate via C-H activation: Preparation and use of 4-trifluoroboratotetrahydroisoquinolones

Potassium vinyltrifluoroborate was found to be an efficient partner with benzamide derivatives for Rh(III)-catalyzed annulations. 4- Trifluoroboratotetrahydroisoquinolones were generated under mild conditions, affording a regioisomerically complementary substitution pattern to other alkenes in related reactions. These new boron-containing building blocks were derivatized by N-arylations, retaining the boron substituent for further elaboration.