223671-15-6

Basic information

• Product Name: 7-BROMO-1-HYDROXYISOQUINOLINE
• Synonyms: 7-BROMO-1-HYDROXYISOQUINOLINE;7-Bromoisocarbostyril;7-BROMO-1-HYDROXYISOQUINOLINE, 98+%;7-bromoisoquinolin-1-ol;7-BroMoisoquinolin-1-one;7-Bromo-1(2H)-isoquinolinone;7-broMoisoquinolin-1(2H)-one;7-Bromoisoquinolin-1-ol, 7-Bromo-1-hydroxy-2-azanaphthalene
• CAS NO: 223671-15-6
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05
• EINECS: -0
• Product Categories: Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Isoquinolines;in stock
• Mol File: 223671-15-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 248-250°C
• Boiling Point: 427.5 °C at 760 mmHg
• Flash Point: 212.4 °C
• Appearance: /
• Density: 1.620±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.63E-07mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.34±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 8405244
• CAS DataBase Reference: 7-BROMO-1-HYDROXYISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-1-HYDROXYISOQUINOLINE(223671-15-6)
• EPA Substance Registry System: 7-BROMO-1-HYDROXYISOQUINOLINE(223671-15-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 223671-15-6(Hazardous Substances Data)

Usage

Description

7-BROMO-1-HYDROXYISOQUINOLINE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. It is characterized by its unique chemical structure, which includes a bromo and hydroxyl group attached to an isoquinoline backbone.

Uses

Used in Pharmaceutical Industry:
7-BROMO-1-HYDROXYISOQUINOLINE is used as a pharmaceutical intermediate for the development and synthesis of various drugs. Its unique chemical structure allows it to be a versatile building block in the creation of new medications with potential therapeutic applications.
Additionally, 7-BROMO-1-HYDROXYISOQUINOLINE is used to prepare 1-amino-4-bromoisoquinoline, which is another important compound in the pharmaceutical industry. 7-BROMO-1-HYDROXYISOQUINOLINE can be further utilized in the synthesis of various drugs with specific therapeutic properties.

InChI:InChI=1/C9H6BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12)

Upstream product

• 108-05-4 vinyl acetate 
• 1427180-45-7 (3-bromophenyl)formamido 2,2-dimethylpropanoate 
• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 215453-51-3 7-bromo-1-chloroisoquinoline 
• 223671-18-9 7-bromo-isoquinoline N-oxide 
• 1122-91-4 4-bromo-benzaldehyde 
• 58794-09-5 7-bromoisoquinoline 
• 27465-66-3 4-bromocinnamoyl chloride 
• 1200-07-3 trans-4-bromocinnamic acid 

Downstream Products

• 215453-53-5 7-bromoisoquinolin-1-amine 
• 444898-46-8 C₃₅H₂₆BrNO₈ 
• 658081-95-9 4-(7-bromo-1-oxo-1H-isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester 
• 658082-39-4 methyl 1-oxo-2H-isoquinoline-7-carboxylate 
• 1374258-54-4 1-(4-methoxybenzylamino)isoquinoline-7-carboxylic acid 
• 1374258-53-3 ethyl 1-(4-methoxybenzylamino)isoquinoline-7-carboxylate 
• 444898-53-7 C₃₆H₂₆N₂O₈ 
• 942119-65-5 1-chloroisoquinoline-7-sulfonyl chloride 
• 223671-79-2 1-chloro-N-phenyl-7-isoquinolinesulphonamide 
• 658082-39-4 methyl 1-hydroxyisoquinoline-7-carboxylate 
• 223671-87-2 7-bromo-4-chloro-2H-isoquinolin-1-one 

Relevant articles and documents

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.

Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport

Artificial ligands of streptavidin (ALiS) with association constants of 106 M-1 were discovered by high-throughput screening of our chemical library, and their binding characteristics, including X-ray crystal structure of the streptavidin complex, were determined. Unlike biotin and its derivatives, ALiS exhibits fast dissociation kinetics and excellent cell permeability. The streptavidin-ALiS system provides a novel, practical compound-dependent methodology for repeated reversible cycling of protein localization between intracellular organella.