142758-86-9

Basic information

• Product Name: (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid
• Synonyms: (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid
• CAS NO: 142758-86-9
• Molecular Weight: 196.633
• Mol File: 142758-86-9.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid(142758-86-9)
• EPA Substance Registry System: (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid(142758-86-9)

Safety Data

• Hazardous Substances Data: 142758-86-9(Hazardous Substances Data)

Upstream product

• 75-47-8 iodoform 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 939-90-2 trans-2-phenylcyclopropane-1-carboxylic acid 
• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 104-88-1 4-chlorobenzaldehyde 
• 1073-67-2 4-vinylbenzyl chloride 
• 100117-11-1 4-Chlor-4-(4-chlor-phenyl)-buttersaeureethylester 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 18410-18-9 γ-(4-chlorophenyl)-γ-butyrolactone 
• 946-38-3 ethyl 2-phenylcyclopropylcarboxylate 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 623-73-4 diazoacetic acid ethyl ester 
• 72228-99-0 methyl trans-2-(p-chlorophenyl)cyclopropanecarboxylate 

Downstream Products

• 31501-86-7 (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid 
• 142793-24-6 (+)-(1S,2S)-2-(4-chlorophenyl)cyclopropanecarboxylic acid 
• 1278662-50-2 (trans-2-(4-chlorophenyl)cyclopropyl)methanol 
• 72228-99-0 methyl trans-2-(p-chlorophenyl)cyclopropanecarboxylate 
• 90794-53-9 trans-2-(4-Chlor-phenyl)-cyclopropan-carbonsaeure-⁽¹⁾-hydrazid 
• 61114-41-8 (±)-trans-2-(4-chlorophenyl)cyclopropan-1-amine 

Relevant articles and documents

PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS

The invention includes procedures for stereoselective β-arylation of carboxylic acids having a β-carbon atom. For example, stereoselective arylation procedures include the following reactions: (I)

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

The synergistic effect of copper chromite spinel nanoparticles (CuCr2O4) and basic ionic liquid on the synthesis of cyclopropanecarboxylic acids

Abstract: An efficient synthesis of cyclopropanecarboxylic acids using copper chromite spinel nanoparticles and basic ionic liquid is described. In this study, a relatively simple method starting with trans-cinnamic acid for the synthesis of (±)-trans-2-phenylcyclopropanecarboxylic acid, a key intermediate in the synthesis of tranylcypromine sulfate as an active pharmaceutical ingredient, was employed. Using a combination of basic ionic liquid [Bmim]OH and copper chromite spinel nanoparticles as a catalytic system, the best results were obtained in THF as a polar solvent. This method is a useful alternative to other approaches described in the literature. The use of commercially available chemicals, decreased environmental hazards, with no need for the separation of stereoisomers, and consequently a reduced number of overall steps, are the advantages of this approach that make it an appropriate choice at an increased scale. Graphical Abstract: [Figure not available: see fulltext.]