1428986-88-2Relevant articles and documents
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening
Lauria, Antonino,Abbate, Ilenia,Gentile, Carla,Angileri, Francesca,Martorana, Annamaria,Almerico, Anna Maria
, p. 3424 - 3428 (2013/06/26)
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding as