2417-42-7

Basic information

• Product Name: N-(3-ACETYLPHENYL)METHANESULFONAMIDE
• Synonyms: AURORA 2941;N-(3-ACETYLPHENYL)METHANESULFONAMIDE
• CAS NO: 2417-42-7
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 213.25
• Mol File: 2417-42-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-ACETYLPHENYL)METHANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-ACETYLPHENYL)METHANESULFONAMIDE(2417-42-7)
• EPA Substance Registry System: N-(3-ACETYLPHENYL)METHANESULFONAMIDE(2417-42-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 2417-42-7(Hazardous Substances Data)

Usage

General Description

N-(3-Acetylphenyl)methanesulfonamide, also known as NAPMSA, is a chemical compound that belongs to the class of sulfonamide compounds. It is characterized by the presence of an acetyl group attached to the phenyl ring of the molecule. NAPMSA is primarily used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and other fine chemicals. It has also been studied for its potential medicinal properties, including its use as an antifungal and antibacterial agent. Additionally, NAPMSA has been investigated for its photochemical and photophysical properties, making it a versatile compound with a range of potential applications in various industries.

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1428986-84-8 C₂₀H₁₈N₄O₃S 
• 1428986-85-9 C₂₁H₂₀N₄O₄S 
• 1428986-86-0 C₂₀H₁₈N₄O₃S 
• 1428986-88-2 C₂₀H₁₈N₄O₄S 
• 1428986-89-3 C₂₀H₁₈N₄O₃S 
• 1428986-90-6 C₂₃H₂₅N₅O₂S 

Relevant articles and documents

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding as

Catecholamine surrogates useful as β3 agonists

Compounds of the formula STR1 or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH 2) n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R 9)R 9'' or --CO 2 R 7 ;R 1 is lower alkyl, aryl or arylalkyl;R 2 is hydrogen, hydroxy, alkoxy, --CH 2 OH, cyano, --C(O)OR 7, --CO 2 H, --CONH 2, tetrazole, --CH 2 NH 2 or halogen; STR2 R 3 is hydrogen, alkyl, heterocycle or R 4 is hydrogen, alkyl or B;R 5, R 5'', R 8, R 8'' or R 8"" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH 2) n NR 6 COR 7, --CON(R 6)R 6'', --CON(R 6)OR 6'', --CO 2 R 6, --SR 7, --SOR 7, --SO 2 R 7, --N(R 6)SO 2 R 1, --N(R 6)R 6'', --NR 6 COR 7, --OCH 2 CON(R 6)R 6'', --OCH 2 CO 2 R 7 or aryl; orR 5 and R 5'' or R 8 and R 8'' may together with the carbon atoms to which they are attached form an aryl or heterocycle;R 6 and R 6'' are independently hydrogen or lower alkyl; andR 7 is lower alkyl;R 9 is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R 9 and R 9'' may together with the nitrogen atom to which they are attached form a heterocycle; with the proviso that when A is a bond or --(CH 2) n and R 3 is hydrogen or unsubstituted alkyl, then R 4 is B or substituted alkyl. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.