1429415-80-4

Basic information

• Product Name: tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
• Synonyms: tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
• CAS NO: 1429415-80-4
• Molecular Weight: 325.838
• Mol File: 1429415-80-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate(1429415-80-4)
• EPA Substance Registry System: tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate(1429415-80-4)

Safety Data

• Hazardous Substances Data: 1429415-80-4(Hazardous Substances Data)

Upstream product

• 460047-89-6 tert-butyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 95-83-0 4-Chloro-1,2-phenylenediamine 

Downstream Products

• 53786-28-0 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one 

Relevant articles and documents

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

PHARMACEUTICAL COMPOUNDS

Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R1is -(CH2)m-R7, (Formula (II)) or (Formula (III)); R2 is H, halo, -(CH2)m-NH2, -(CH2)n-C(=NH)-NH2 or -(CH2)n-NH-(CH2)m-NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, -SO2R11, -NH-(CH2)2-(NH)r-R8, -NH-CH(R8R9) or a group of the following formula (A): (Formula (A)): W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2-, -(CH2)r-S(O)2-CH2-or -(CH2)r-NR8-CH2-; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R8 is H, -SO2R11,-SO2CF3, -COR11, -C(O)OR11, -CON(R9)2 or -(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is -SO2R11, -SO2CF3, -COR11, -CON(R9)2 or -(CH2)nSO2R11; and R11 is C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Concise and simple synthesis of M1 allosteric agonist TBPB

A concise and simple synthesis of M1 allosteric agonist 1-(1′-(2-methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d] imidazol-2(3H)-one (TBPB) using economical and commercially available orthophenylenediamine (O-PDA) and Boc piperidone has been described. The disclosed scheme allows synthesizing more analogs that were otherwise difficult to prepare with the original method. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.