460047-89-6

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[(4-chloro-2-nitrophenyl)amino]-, 1,1-dimethylethyl ester
• CAS NO: 460047-89-6
• Molecular Formula: C16H22ClN3O4
• Molecular Weight: 355.821
• Mol File: 460047-89-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[(4-chloro-2-nitrophenyl)amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[(4-chloro-2-nitrophenyl)amino]-, 1,1-dimethylethyl ester(460047-89-6)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[(4-chloro-2-nitrophenyl)amino]-, 1,1-dimethylethyl ester(460047-89-6)

Safety Data

• Hazardous Substances Data: 460047-89-6(Hazardous Substances Data)

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 89-61-2 2,5-dichloronitrobenzene 
• 345-18-6 2-fluoro-5-chloronitrobenzene 

Downstream Products

• 1429415-80-4 tert-butyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate 
• 53786-28-0 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 918535-44-1 C₂₈H₃₇ClN₆O₅ 

Relevant articles and documents

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

PHARMACEUTICAL COMPOUNDS

Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R1is -(CH2)m-R7, (Formula (II)) or (Formula (III)); R2 is H, halo, -(CH2)m-NH2, -(CH2)n-C(=NH)-NH2 or -(CH2)n-NH-(CH2)m-NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, -SO2R11, -NH-(CH2)2-(NH)r-R8, -NH-CH(R8R9) or a group of the following formula (A): (Formula (A)): W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2-, -(CH2)r-S(O)2-CH2-or -(CH2)r-NR8-CH2-; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R8 is H, -SO2R11,-SO2CF3, -COR11, -C(O)OR11, -CON(R9)2 or -(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is -SO2R11, -SO2CF3, -COR11, -CON(R9)2 or -(CH2)nSO2R11; and R11 is C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

PIPERIDINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS

Disclosed are novel compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR7)