14300-33-5

Basic information

• Product Name: DICYCLOPROPYLMETHANOL
• Synonyms: Cyclopropanemethanol, alpha-cyclopropyl-;DCPM-OH;DICYCLOPROPYL CARBINOL;DICYCLOPROPYLMETHANOL;Biscyclopropylmethanol;Dicyclopropylmethyl alcohol;Einecs 238-236-3;Dicyclopropyl carbinol 97%
• CAS NO: 14300-33-5
• Molecular Formula: C₇H₁₂O
• Molecular Weight: 112.17
• EINECS: 238-236-3
• Mol File: 14300-33-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 69 °C13 mm Hg(lit.)
• Flash Point: >110°C
• Appearance: /
• Density: 0.951 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.357mmHg at 25°C
• Refractive Index: n20/D 1.464
• Storage Temp.: 2-8°C
• PKA: 15.04±0.20(Predicted)
• Water Solubility: Sparingly soluble in water.
• BRN: 2203215
• CAS DataBase Reference: DICYCLOPROPYLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: DICYCLOPROPYLMETHANOL(14300-33-5)
• EPA Substance Registry System: DICYCLOPROPYLMETHANOL(14300-33-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 14300-33-5(Hazardous Substances Data)

Usage

Description

Dicyclopropylmethanol, a synthetic organic compound, is characterized by its unique bicyclic structure and hydroxyl functional group. It is known for its ability to form esters with carboxylic acids, which can be selectively and mildly cleaved, making it a valuable reagent in organic chemistry.

Uses

Used in Chemical Synthesis:
Dicyclopropylmethanol is used as a protecting group reagent for carboxylic acids. The formed esters provide a means to temporarily shield the carboxylic acid functionality during chemical reactions, preventing unwanted side reactions. This selective protection is particularly useful in multi-step synthesis processes, where the integrity of the carboxylic acid group must be maintained until a specific reaction step.
The mild and selective cleavage of the esters formed with dicyclopropylmethanol allows for the controlled deprotection of the carboxylic acid, ensuring minimal disruption to the rest of the molecule and facilitating the completion of the desired synthesis. This application is crucial in the development of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.

InChI:InChI=1/C7H12O/c8-7(5-1-2-5)6-3-4-6/h5-8H,1-4H2

Upstream product

• 23719-80-4 cyclopropylmagnesium bromide 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 1121-37-5 dicyclopropyl ketone 

Downstream Products

• 118285-30-6 (dicyclopropylmethoxy)acetic acid ethyl ester 
• 51043-72-2 bis(cyclopropyl)methylamine hydrochloride 
• 1154472-19-1 4-benzyl-8-(1-dicyclopropylmethoxy)-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine 
• 802911-34-8 (2S,3S)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester 
• 802911-33-7 (2S,3S)-2-((2S,3R)-2-Benzyloxycarbonylamino-3-phenyl-butyrylamino)-3-methyl-pentanoic acid dicyclopropylmethyl ester 
• 23772-96-5 1,2-Dicyclopropyl-2-phenylaethylen 

Relevant articles and documents

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CaSR ANTAGONIST

The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.

REACTION OF DICYCLOPROPYL KETONE WITH LiAlH4 AND TiCl4

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