1430210-53-9Relevant articles and documents
Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist
Agarwal, Sameer,Patil, Amit,Aware, Umesh,Deshmukh, Prashant,Darji, Brijesh,Sasane, Santosh,Sairam, Kalapatapu V. V. M.,Priyadarsiny, Priyanka,Giri, Poonam,Patel, Harilal,Giri, Suresh,Jain, Mukul,Desai, Ranjit C.
, p. 51 - 55 (2016/02/03)
TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5