23023-16-7

Basic information

• Product Name: 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE
• Synonyms: 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE
• CAS NO: 23023-16-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 23023-16-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 130-140 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.039±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE(23023-16-7)
• EPA Substance Registry System: 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE(23023-16-7)

Safety Data

• Hazardous Substances Data: 23023-16-7(Hazardous Substances Data)

Usage

General Description

2-(3,4-Dimethoxyphenyl)-2-methylpropanenitrile, also known as 2,4-Dimethoxy-alpha-tolunitrile, is a chemical compound with the molecular formula C12H15NO2. It is a nitrile derivative that contains a nitrile group and two methoxy (CH3O) groups attached to a benzene ring. 2-(3,4-DIMETHOXYPHENYL)-2-METHYLPROPANENITRILE is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has been studied for its potential biological activities, including its anti-tumor and anti-inflammatory properties. Its structure and properties make it a valuable component in the production of diverse chemical and pharmaceutical products.

Upstream product

• 78-82-0 Isobutyronitrile 
• 398-62-9 4-fluoroveratrole 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 74-88-4 methyl iodide 
• 51698-53-4 2‐(3,4‐dimethoxyphenyl)propionitrile 

Downstream Products

• 1430211-17-8 5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indazole 
• 1430211-02-1 5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indole 
• 1430210-74-4 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-2-((2-(2-fluoro-4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-73-3 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-2-((2-(2-fluoro-4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-67-5 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-(4-(2-methyl-1H-imidazol-1-yl)phenoxy)ethyl)thio)-1H-imidazole 
• 1430210-54-0 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-68-6 1-(4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)phenyl)-1H-1,2,4-triazole 
• 1430210-71-1 1-(4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)phenyl)-1H-pyrazole 
• 1430210-53-9 2-((2-(4-(1H-pyrrol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole 
• 1430210-58-4 4-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)benzonitrile 
• 1430211-24-7 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-2-((2-phenoxyethyl)thio)-1H-imidazole 
• 1239963-74-6 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol 
• 1430211-87-2 1-bromo-3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one 
• 4461-99-8 3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one 

Relevant articles and documents

Catalytic asymmetric addition of dialkylzinc to 3,4-dihydroisoquinoline N-oxides utilizing tartaric acid ester as a chiral auxiliary

The catalytic asymmetric addition of dialkylzinc to a carbon-nitrogen double bond in 3,4-dihydroisoquinoline N-oxides was achieved by utilizing a catalytic amount of 2-magnesium 3-zinc salt of dicyclopentyl (R,R)-tartrate to afford (S)-1-alkyl-2-hydroxy-1

Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor 1, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.

A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromans

An unprecedented method that enables the direct coupling of an α-C-H bond in alcohols with 2-arylacetaldehydes through a [1,3]-hydride transfer ([1,3]-HT) of oxocarbenium ions catalyzed by a Lewis acid has been developed. The redox neutral preparation of