398-62-9 Usage
Description
1,2-DIMETHOXY-4-FLUOROBENZENE is an organic compound characterized by its white to light yellow crystalline appearance. It is a derivative of benzene with a fluorine atom at the 4-position and two methoxy groups at the 1 and 2 positions. 1,2-DIMETHOXY-4-FLUOROBENZENE is known for its stability and reactivity, making it a versatile building block in organic synthesis.
Uses
Used in Organic Synthesis:
1,2-DIMETHOXY-4-FLUOROBENZENE is used as a raw material for the synthesis of various organic compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,2-DIMETHOXY-4-FLUOROBENZENE is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can influence the biological activity and pharmacokinetic properties of the final drug product, making it an essential component in drug discovery and development.
Used in Agrochemical Industry:
1,2-DIMETHOXY-4-FLUOROBENZENE is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other crop protection products. Its incorporation into these molecules can enhance their efficacy, selectivity, and environmental compatibility.
Used in Chemical Research:
In the field of chemical research, 1,2-DIMETHOXY-4-FLUOROBENZENE serves as a model compound for studying various reaction mechanisms and exploring new synthetic methodologies. Its unique reactivity and stability make it an ideal candidate for testing new catalysts, reagents, and reaction conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 398-62-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 398-62:
(5*3)+(4*9)+(3*8)+(2*6)+(1*2)=89
89 % 10 = 9
So 398-62-9 is a valid CAS Registry Number.
398-62-9Relevant articles and documents
An improved synthesis of 4-fluoroveratrole. Efficient route to 6-fluoroveratraldehyde and 6-fluoro-D,L-DOPA
Furlano,Kirk
, p. 4073 - 4075 (1986)
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Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination
Li, Jiakun,Chen, Junting,Sang, Ruocheng,Ham, Won-Seok,Plutschack, Matthew B.,Berger, Florian,Chabbra, Sonia,Schnegg, Alexander,Genicot, Christophe,Ritter, Tobias
, p. 56 - 62 (2019/11/28)
Photoredox catalysis, especially in combination with transition metal catalysis, can produce redox states of transition metal catalysts to facilitate challenging bond formations that are not readily accessible in conventional redox catalysis. For arene functionalization, metallophotoredox catalysis has successfully made use of the same leaving groups as those valuable in conventional cross-coupling catalysis, such as bromide. Yet the redox potentials of common photoredox catalysts are not sufficient to reduce most aryl bromides, so synthetically useful aryl radicals are often not directly available. Therefore, the development of a distinct leaving group more appropriately matched in redox potential could enable new reactivity manifolds for metallophotoredox catalysis, especially if arylcopper(iii) complexes are accessible, from which the most challenging bond-forming reactions can occur. Here we show the conceptual advantages of aryl thianthrenium salts for metallophotoredox catalysis, and their utility in site-selective late-stage aromatic fluorination.
Hypervalent Iodine(III)-Catalyzed Balz–Schiemann Fluorination under Mild Conditions
Xing, Bo,Ni, Chuanfa,Hu, Jinbo
, p. 9896 - 9900 (2018/07/31)
An unprecedented hypervalent iodine(III) catalyzed Balz–Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25–60 °C), and features a wide substrate scope and good functional-group compatibility.
