143191-63-3

Basic information

• Product Name: 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-
• CAS NO: 143191-63-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 143191-63-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-(143191-63-3)
• EPA Substance Registry System: 1-Propanone, 2-hydroxy-1-(4-methoxyphenyl)-, (R)-(143191-63-3)

Safety Data

• Hazardous Substances Data: 143191-63-3(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 75-07-0 acetaldehyde 
• 530085-88-2 phosphoric acid diethyl ester 1-(4-methoxyphenyl)-propenyl ester 
• 121-97-1 4-Methoxypropiophenone 
• 10557-27-4 1-(4-methoxy-phenyl)-propane-1,2-dione 
• 200353-84-0 1-(4-methoxyphenyl)-1-oxopropan-2-yl acetate 
• 143215-10-5 (Z)-1-(4-methoxyphenyl)-1-(tert-butyldimethylsiloxy)-1-propene 
• 58889-89-7 (Z)-1-methoxy-1-(4-methoxyphenyl)-1-propene 

Relevant articles and documents

α-Hydroxy Ketones in High Enantiomeric Purity from Asymmetric Dihydroxylation of Enol Ethers

Highly enantioselective construction of α-hydroxy ketones by the osmium-catalyzed asymmetric dihydroxylation of the corresponding enol ethers has been achieved.

Biocatalytic route to chiral acyloins: P450-catalyzed regio- and enantioselective α-hydroxylation of ketones

P450-BM3 and mutants of this monooxygenase generated by directed evolution are excellent catalysts for the oxidative α-hydroxylation of ketones with formation of chiral acyloins with high regioselectivity (up to 99%) and enantioselectivity (up to 99% ee). This constitutes a new route to a class of chiral compounds that are useful intermediates in the synthesis of many kinds of biologically active compounds.

Studies towards the stereoselective α-hydroxylation of flavanones. Biosynthetic significance

The enolates of various propiophenones, chromanones, and also analogues of naturally occurring flavanones were stereoselectively hydroxylated at the ?-position, by employing commercially available enantiopure oxaziridines, to afford the desired ?-hydroxylated target molecules in good to exceptional stereoselectivities and in moderate to good chemical yields. A mechanistic rationale is presented to account for the stereoselectivities achieved. These in vitro results were tentatively related to the stereoselective biosynthesis of enantio-enriched dihydroflavonols while questions were raised about the authenticity of certain natural compounds. CSIRO 2008.

α-Hydroxy ketones in high enantiomeric purity from asymmetric oxidation of enol phosphates with (salen) manganese(III) complex

Optically active α-hydroxy ketones 4 have been prepared in high enantioselectivity by the catalytic, enantioselective oxidation of easily available and stable (E)-enol phosphates 2 by (salen) Mn(III) complex.