143557-91-9Relevant articles and documents
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation
Avenoza, Alberto,Bernardes, Gon?alo J. L.,Busto, Jesús H.,Corzana, Francisco,Ferhati, Xhenti,García-Sanmartín, Josune,Garrido, Pablo,Guerreiro, Ana,Jiménez-Moreno, Ester,Martínez, Alfredo,Peregrina, Jesús M.,Salas-Cubero, Marina
supporting information, p. 8580 - 8584 (2021/11/17)
A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promo
AZABENZIMIDAZOLE COMPOUNDS AND PHARMACEUTICAL
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Paragraph 0360, (2021/03/18)
The purpose of the present invention is to provide compounds having an M3 PAM action. Examples of the present invention include azabenzimidazole compounds represented, for example, by formula [I], and pharmacologically acceptable salts thereof. These comp
MODULATION OF N-ACYLETHANOLAMINE-HYDROLYSING ACID AMIDASE (NAAA) FOR DISEASE TREATMENT
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Paragraph 0025-0029, (2019/05/18)
Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolysing acid amidase (NAAA), may be used for the therapeutical treatment and prevention of pain and inflammatory disorders and other disorders which benefit from