143767-56-0

Basic information

• Product Name: (-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• Synonyms: (-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• CAS NO: 143767-56-0
• Molecular Weight: 315.456
• Mol File: 143767-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate(143767-56-0)
• EPA Substance Registry System: (-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate(143767-56-0)

Safety Data

• Hazardous Substances Data: 143767-56-0(Hazardous Substances Data)

Upstream product

• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 2216-51-5 (-)-menthol 
• 143767-54-8 (R,S)-2-acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 612-12-4 o-Xylylene dichloride 
• 143767-55-9 dimethyl 2-acetyl-1,2,3,4-tetrahydroisoquinoline-3,3-dicarboxylate 
• 91-13-4 α,α'-dibromo-o-xylene 

Downstream Products

• 74163-81-8 L-Tic-OH 

Relevant articles and documents

Efficient synthesis of racemic and enantiomerically pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and esters

Racemic and optically pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and esters were prepared, via base-catalyzed cyclization of 1,2-bis(halomethyl)benzenes 1a or b with diethyl 2-(acetylamino)malonate (2), subsequent decarboxylation and amide cleavage. The enantiomer resolution was achieved either by esterification with (-)-menthol followed by column chromatographic separation of the diastereomeric mixture or by diasteromeric salt separation of the benzylic ester with mandelic acid and base-catalyzed saponification of both esters.