143806-23-9Relevant articles and documents
Five-membered azole heterocyclic compound and its preparation method, pharmaceutical composition and use thereof
-
Paragraph 0644; 0645; 0646; 0657; 0658, (2017/02/28)
The present invention relates to a five-membered azole heterocycle compound represented by the following general formula (I), a preparation method of the five-membered azole heterocycle compound, a drug composition of the five-membered azole heterocycle compound, and a use of the five-membered azole heterocycle compound in preparation of drugs for prevention or treatment of TGR5-mediated diseases. The formula (I) is represented by the instruction.
Regioselective synthesis of polysubstituted pyridines via hetero-Diels-Alder reaction of isotellurazoles with acetylenic dienophiles
Shimada, Kazuaki,Takata, Yukichi,Osaki, Yu,Moro-oka, Akiko,Kogawa, Hisashi,Sakuraba, Maiko,Aoyagi, Shigenobu,Takikawa, Yuji,Ogawa, Satoshi
scheme or table, p. 6651 - 6653 (2010/03/01)
Treatment of substituted isotellurazoles or their Te-oxides with acetylenic dienophiles efficiently afforded polysubstituted pyridine derivatives through a pathway involving hetero-Diels-Alder reaction of isotellurazoles and the subsequent tellurium extru
Regioselective Addition ofd Copper-Zinc Aryl Organometallic Reagents to 3-substituted Pyridinium Salts
Shiao, Min-Jen,Chia, Win-Long,Shing, Tai-Li,Chow, Tahsin J.
, p. 2101 - 2121 (2007/10/02)
A number of 3-substituted pyridinium salts are subjected to nucleophilic addition by copper-zinc aryl organometallic reagents.The adducts are oxidized subsequently to form the corresponding 4-arylpyridines.In all the cases 1,4-addition products are obtained predominantly.The regioselectivity can be rationalized according to the hard-soft acid-base principle.Calculations on both charge distributions and FMO coefficients indicate that these reactions may be classified on the basis of the type of soft acid-soft base reactions.The observed γ-attack complies very well with the orientation of the FMO coefficients as estimated by a semiempirical method.