5470-70-2Relevant articles and documents
60Co γ-Irradiation: Homolytic Alkylation of Methyl Nicotinate
Newkome, George R.,Marston, Charles R.
, p. 4162 - 4163 (1985)
-
Imidacloprid hapten, complete antigen and its preparation method and application
-
Paragraph 0029; 0036, (2018/05/01)
The invention discloses an imidacloprid hapten, complete antigen and its preparation method and an application. The imidacloprid hapten is prepared by taking 6-methyl nicotinic acid, and reacting withmethanol to generate methyl 6-methylnicotinate; reacting methyl 6-methylnicotinate with N-bromosuccinimide to obtain 6-( bromomethyl) methyl nicotinate, and then reacting with N-( imidazolidine-2- subunit) nitramide to generate 6-((2-(nitroamino)imidazoline-1-radical)methyl) methyl nicotinate; finally, reacting ester to be 6-((2-(nitroamino)imidazoline-1-radical)methyl) nicotinic acid by NaOH solution. The imidacloprid hapten is coupled with carrier protein, and the imidacloprid complete antigen is prepared. The immune animal experiment indicates that the artificial antigen has good immunogenicity; the imidacloprid hapten and imidacloprid antigen can be applied to imidacloprid immunoassay analysis; the application prospect is very extensive.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
-
Paragraph 0152; 0153; 0154, (2015/07/07)
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.