226718-32-7

Basic information

• Product Name: 4-(2,4-difluorobenzyl)nicotinic acid
• Synonyms: 4-(2,4-difluorobenzyl)nicotinic acid
• CAS NO: 226718-32-7
• Molecular Weight: 263.244
• Mol File: 226718-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,4-difluorobenzyl)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-difluorobenzyl)nicotinic acid(226718-32-7)
• EPA Substance Registry System: 4-(2,4-difluorobenzyl)nicotinic acid(226718-32-7)

Safety Data

• Hazardous Substances Data: 226718-32-7(Hazardous Substances Data)

Upstream product

• 226718-27-0 methyl 6-methyl-4-(2,4-difluorobenzyl)nicotinate 
• 5470-70-2 Methyl 6-methylnicotinate 
• 226718-21-4 methyl 6-methyl-1-phenoxycarbonyl-4-(2,4-difluorobenzyl)-1,4-dihydronicotinate 

Relevant articles and documents

General synthetic pathway to oxygenated 3-methylbenz[g]isoquinoline- 5,10-diones

The synthesis of naturally occurring dioxygenated and trioxygenated 3- methylbenz[g]isoquinoline-5,10-diones has been accomplished. The critical step involved regioselective additions of di- or trifluorobenzylzinc bromides to activated methyl 6-methylnicotinate. Aromatizations of the resultant dihydropyridines followed by hydrolysis led to the corresponding benzylpyridinecarboxylic acids which on annulative-oxidations led to the respective difluoro- or trifluorobenz[g]isoquinoline-5,10-diones. Displacements of fluorides by methoxide led to the di- or trimethoxy analogues which on selective demethylations led to bostrycoidin, 8-O- methylbostrycoidin, tolypocladin, 5-deoxybostrycoidin or 5-deoxy-6-O-methyl- bostrycoidin. The synthesis of isobostrycoidin and isotolypocladin has also been accomplished.