144125-06-4Relevant articles and documents
Synthesis and selective recognition toward zinc ion of chiral poly(imine-triazole)
Zhou, Jinting,Lu, Wei,Hu, Fangyu,Zhang, Mengyu,Jiang, Liming,Shen, Zhiquan
, p. 2248 - 2257 (2014/07/21)
A novel AB type of clickable monomer, (S)-2-[(2-azido-1-phenylethylimino) methyl]-5-propargyloxyphenol (AMPP) was designed and polymerized to yield a class of main-chain chiral poly(imine-triazole)s through the metal-free click reaction. With the thermally induced polymerization, the desired polytriazoles can be easily prepared in high yields by a stepwise heating-up process and have the number-average molecular masses ranging from 5.1 × 103 to 58.1 × 103 (polydispersity indices = 1.38-1.68). The polymers were characterized by Fourier Transform Infrared spectroscopy (FTIR), 1H Nuclear Magnetic Resonance (NMR), and gel permeation chromatography, and their optical properties were studied by fluorescence and circular dichroism (CD) spectroscopies. As a chemosensor, these polymers exhibited a selective "turn-on" fluorescence enhancement response toward Zn2+ ion over other cations such as Na+, K +, Mg2+, Ca2+, Ag+, Pb2+, Cd2+, Hg2+, Mn2+, and Ni2+ in dimethyl sulfoxide. However, the Zn2+-induced fluorescence signal was subject to serious interference by Al3+, Cu2+, Cr 3+, and Fe3+ ions. Interestingly, the chiral polymer showed distinctive changes in the CD spectra on complexation with Zn 2+, which allowed for the discrimination of this ion in the presence of other species tested including those interfering ions observed in the fluorescent detection.
BICYCLIC AZAHETEROCYCLIC CARBOXAMIDES AS INHIBITORS OF THE KINASE P70S6K
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, (2012/02/13)
The invention provides novel bicyclic azaheterocyciic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
Syntheis of new chiral 5,6,7,8-tetrahydrotetrazolo[1,5-a]pyrazines from α-amino acid derivatives following "click" chemistry
Mohapatra, Debendra K.,Maity, Pradip K.,Ghorpade, Ravindra V.,Gurjar, Mukund K.
scheme or table, p. 865 - 872 (2010/09/16)
An efficient and practical synthesis of new chiral fused tetrazoles have been synthesized following [3+2] cycloaddition reaction starting from α-amino acid derivatives.