144243-28-7

Basic information

• Product Name: 3-(1-PYRROLIDINYL)-PIPERIDINE
• Synonyms: 3-(1-PYRROLIDINYL)-PIPERIDINE;3-PYRROLIDIN-1-YL-PIPERIDINE;3-(1-pyrrolidinyl)piperidine(SALTDATA: 2HCl);3-(1-Pyrrolidinyl)-piperidine 2HCl
• CAS NO: 144243-28-7
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.26
• Mol File: 144243-28-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231°C at 760 mmHg
• Flash Point: 93.8°C
• Appearance: /
• Density: 0.989g/cm³
• Vapor Pressure: 0.0637mmHg at 25°C
• Refractive Index: 1.507
• PKA: 10.28±0.20(Predicted)
• CAS DataBase Reference: 3-(1-PYRROLIDINYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-PYRROLIDINYL)-PIPERIDINE(144243-28-7)
• EPA Substance Registry System: 3-(1-PYRROLIDINYL)-PIPERIDINE(144243-28-7)

Safety Data

• Hazardous Substances Data: 144243-28-7(Hazardous Substances Data)

Usage

General Description

3-(1-Pyrrolidinyl)-piperidine is an organic compound with the molecular formula C11H20N2. It is a heterocyclic chemical containing a piperidine ring and a pyrrolidine ring, and is commonly used as a building block in the synthesis of pharmaceutical drugs and other organic compounds. This chemical has a wide range of applications, including in the production of antiviral and antipsychotic medications, as well as in the synthesis of various fine chemicals and pharmaceutical intermediates. 3-(1-Pyrrolidinyl)-piperidine is a versatile and important compound in the field of organic chemistry and drug development.

InChI:InChI=1/C9H18N2/c1-2-7-11(6-1)9-4-3-5-10-8-9/h9-10H,1-8H2

Upstream product

• 72692-99-0 3-(1H-pyrrol-1-yl)pyridine 
• 144243-26-5 1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine 
• 144243-27-6 1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine fumarate 

Downstream Products

• 144243-30-1 3-(1-pyrrolidinyl)-1-<(3,4-dichlorophenyl)acetyl>piperidine 
• 144243-05-0 3-(1-pyrrolidinyl)-1-<2-(3,4-dichlorophenyl)ethyl>piperidine 

Relevant articles and documents

Simple method for the synthesis of 3-(pyrrolidin-1-yl)piperidine

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Synthesis and Biological Evaluation of Conformationally Restricted 2-(1-Pyrrolidinyl)-N--N-methylethylenediamines as ? Receptor Ligands. 1. Pyrrolidine, Piperidine, Homopiperidine, and Tetrahydroisoquinoline Classes

The synthesis and ? receptor affinity of a series of conformationally restricted derivatives of 2-(1-pyrrolidinyl)-N--N-methylethylenediamine (1) is described.The pyrrolidinyl (or N,N-dialkyl), ethylenediamine, N-alkyl, and phenylethyl portions of this ? receptor pharmacophore were restricted by its incorporation into 1,2-cyclohexanediamine-, pyrrolidine-, piperidine-, homopiperidine-, and tetrahydroisoquinoline-containing ligands.The ? receptor binding affinities of these compounds were determined using (+)-pentazocine in guinea pig brain homogenates.The synthesis of all but one class was achieved by acylation and alane reduction of the appropriate diamine precursors whose synthesis is also reported. ? receptor affinities ranged from 1.34 nM for 6,7-dichloro-2-tetrahydroisoquinoline (12) to 455 nM for (1R,2R)-trans-N--N-methyl-2-(1-pyrrolidinyl)cyclohexylamine .In this displacement assay, (+)-pentazocine exhibited a Ki of 3.1 nM while DTG and haloperidol showed Ki values of 27.7 and 3.7 nM, respectively.The conformationally free parent compound 1 exhibited a Ki value of 2.1 nM.Comparison of both the ? receptor affinities and nitrogen atom geometry of the compounds revealed that a gauche relation of the nitrogen atoms of cis-1,2-cyclohexanediamines is not imperative for high affinity as we had previously thought.It is highly likely that nitrogen lone pair orientations and steric factors on the aliphatic portions of these ligands play a major role in the ? receptor binding of this pharmacophore.