1443215-58-4

Basic information

• Product Name: 3-oxo-3-(p-tolyl)prop-1-en-2-yl acetate
• Synonyms: 3-oxo-3-(p-tolyl)prop-1-en-2-yl acetate
• CAS NO: 1443215-58-4
• Molecular Weight: 204.225
• Mol File: 1443215-58-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-oxo-3-(p-tolyl)prop-1-en-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-3-(p-tolyl)prop-1-en-2-yl acetate(1443215-58-4)
• EPA Substance Registry System: 3-oxo-3-(p-tolyl)prop-1-en-2-yl acetate(1443215-58-4)

Safety Data

• Hazardous Substances Data: 1443215-58-4(Hazardous Substances Data)

Upstream product

• 19832-78-1 1-(4-methylphenyl)prop-2-en-1-one 
• 64-19-7 acetic acid 
• 2749-93-1 1-methyl-4-(1-propyn-1-yl)benzene 
• 3375-31-3 palladium diacetate 
• 1855-08-9 1-(p-Tolyl)-1,2-propanedione 
• 108-24-7 acetic anhydride 
• 5337-93-9 4'-methylpropiophenone 

Downstream Products

• 1443215-62-0 (R)-1-oxo-1-(p-tolyl)propan-2-yl acetate 
• 1855-08-9 1-(p-Tolyl)-1,2-propanedione 

Relevant articles and documents

A General Method for α-Oxyacylation of Vinyl Ketones Using Koser's Reagent

A direct general method for the preparation of α-oxyacylated vinyl ketones using Koser's hypervalent iodine reagent is reported. A variety of acyloxy groups from long-chain aliphatic, aromatic, α,β-unsaturated carboxylic acids have been installed efficiently for the first time. The oxyacylated adducts were used for the preparation of densely functionalized chiral δ-lactones and cyclopentenes using carbene organocatalysis.

An Unprecedented (Semi)Favorskii rearrangement. evidence for the 2-(Acyloxy)cyclopropanones

Discovery and development of an unprecedented (semi)Favorskii rearrangement has been reported. The intermediacy of structurally singular (acyloxy)cyclopropanones has been unraveled by fruitful control experiments including a crossover experiment. This class of cyclopropanones is found to be inert for classical Favorskii functionalization and preferably undergoes a decycloisomerization (ring-chain valence tautomerism) to α-(acyloxy)enones. A cascade conversion of α,α-diiodo-α′-acetoxyketones to (acyloxy)cyclopropanones via α-iodo-α′-acetoxyketones has been achieved by the synchronous dual basicity (Lewis and Br?nsted) of amines. The overall process is found to be very general for diverse substrates and highly efficient.

A simple synthetic route to enantiopure α-hydroxy ketone derivatives by asymmetric hydrogenation

High enantioselectivities (up to 99% ee) have been observed for the catalytic asymmetric hydrogenation of the α-ketone enol acetates. DuanPhos has been proved to be the most effective ligand for this reaction. The high yield and enantioselectivity of the asymmetric hydrogenation of the α-ketone enol acetates represents a feasible synthetic route to important pharmaceutical building blocks: α-hydroxy ketones. Copyright