1443441-67-5Relevant articles and documents
A pharmaceutical intermediates substituted furyl synthetic method of compound
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Paragraph 0033-0036, (2017/08/25)
The invention relates to a synthetic method for a polysubstituted furan compound as shown in the following formula (III). The synthetic method comprises the following steps: under the air atmosphere, in the presence of a catalyst, an oxidizing agent, an additive and soda, stirring a compound as shown in a formula (I) of the description and a compound as shown in a formula (II) of the description in an organic solvent at the temperature of 60-80 DEG C to enable the mixture to react for 7-10 hours, after the reaction, performing after-treatment to obtain the compound as shown in the formula (III) of the description, wherein each of R1and R2 is independently selected from H or C1-C6 alkyl; R3 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen; X is a halogen. According to the method, through the use of a suitable substrate as well as selection and synergism of the catalyst, the oxidizing agent, the additive, soda and the organic solvent, a high-yield target product can be obtained; the synthetic method has an excellent application prospect and a wide industrial production potentiality in the technical field of drug intermediate synthesis.
A co-operative effect of visible light photo-catalysis and CoFe2O4 nanoparticles for green synthesis of furans in water
Verma, Fooleswar,Singh, Puneet K.,Bhardiya, Smita R.,Singh, Manorama,Rai, Ankita,Rai, Vijai K.
supporting information, p. 4937 - 4942 (2017/07/12)
A novel approach to poly-functionalized furan synthesis is disclosed via oxidative decarboxylative [3+2] cycloaddition using co-operative catalysis by visible light and CoFe2O4 nanoparticles under ambient reaction conditions with water as a solvent. Although the reported method is efficient without catalyst in the presence of visible light (70% yield in 4 h at rt), the use of catalyst not only increases the yield (91%) but also accelerates the conversion rate (2 h at rt).
Visible-Light Induced Direct Synthesis of Polysubstituted Furans from Cyclopropyl Ketones
Feng, Liyan,Yan, Hang,Yang, Chao,Chen, Dafa,Xia, Wujiong
, p. 7008 - 7022 (2016/08/30)
In this article, a photoredox protocol for the synthesis of furans via oxidative coupling of olefin generated in situ from cyclopropyl ketones with ketonic oxygen atom is presented. Moreover, bromination of furans in the presence of overstoichiometric oxidant has been achieved with high regioselectivity.