144452-46-0

Basic information

• Product Name: Benzenepropanoyl chloride, b-(dimethylphenylsilyl)-, (R)-
• CAS NO: 144452-46-0
• Molecular Formula: C17H19ClOSi
• Molecular Weight: 302.876
• Mol File: 144452-46-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenepropanoyl chloride, b-(dimethylphenylsilyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, b-(dimethylphenylsilyl)-, (R)-(144452-46-0)
• EPA Substance Registry System: Benzenepropanoyl chloride, b-(dimethylphenylsilyl)-, (R)-(144452-46-0)

Safety Data

• Hazardous Substances Data: 144452-46-0(Hazardous Substances Data)

Upstream product

• 153221-16-0 (R)-3-(dimethylphenylsilyl)-3-(phenyl)propanoic acid 
• 109053-73-8 (3aS,6R,7aR)-8,8-dimethyl-1-[(2E)-3-phenylprop-2-enoyl]hexahydro-3a,6-methano-2,1-benzisothiazole 2,2-dioxide 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 148003-99-0 benzyl (3RS)-3-dimethyl(phenyl)silyl-3-phenylpropanoate 
• 94286-44-9 3-dimethyl(phenyl)silyl-3-phenylpropan-1-ol 
• 98-88-4 benzoyl chloride 
• 17909-51-2 (dimethyl(phenyl)silyl)(phenyl)methanone 
• 1468-28-6 4-benzoylmorpholine 
• 889129-99-1 ethyl (Z)-3-(dimethyl(phenyl)silyl)-3-phenyl-2-propenoate 
• 889130-06-7 (R)-3-(dimethylphenylsilyl)-3-phenylpropanoic acid ethyl ester 
• 103-26-4 Methyl cinnamate 
• 94286-28-9 4-(dimethylphenylsilyl)-3-phenylpropanoic acid methyl ester 
• 4192-77-2 ethyl cinnamate 
• 67263-05-2 ethyl 3-(dimethyl(phenyl)silyl)-3-phenylpropionate 

Downstream Products

• 144452-48-2 (2R,3R)-2-tert-Butoxycarbonylamino-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-succinic acid dimethyl ester 
• 144452-47-1 (2R,3R)-2-Amino-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-succinic acid dimethyl ester 
• 144452-49-3 (2R,3R)-2-Benzyl-3-tert-butoxycarbonylamino-succinic acid dimethyl ester 
• 138235-14-0 (2R,3R)-3-[(R)-(Dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester 
• 144539-95-7 (2R,3R)-1-[Bis-(4-methoxy-phenyl)-methyl]-3-[(R)-(dimethyl-phenyl-silanyl)-phenyl-methyl]-4-oxo-azetidine-2-carboxylic acid methyl ester 
• 212180-93-3 4-(Dimethyl-phenyl-silanyl)-4-phenyl-butyryl azide 
• 212180-75-1 4-(Dimethyl-phenyl-silanyl)-4-phenyl-butyric acid hydrazide 

Relevant articles and documents

Chiral silanes via asymmetric hydrosilylation with catalytic CuH

CuH-catalyzed asymmetric conjugate reduction of β-silyl-α, β-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)2 leads to highly enantioselective 1,4-reductions.

Construction of quaternary stereogenic centers via [2 + 2] cycloaddition reactions. Synthesis of homochiral 4,4-disubstituted 2-azetidinones and imine substituent effects on β-lactam formation

A study on the asymmetric construction of quaternary stereogenic centers via [2 + 2] cycloaddition reaction of ketenes with ketimines is described. Reaction of achiral ketenes and chiral α-alkoxy ketone-derived imines resulted in formation of new β-lactams as single diastereomers. The cycloaddition was extended to pyruvate imines, aralkyl ketone-derived imines, and dialkyl ketimines. In these cases the asymmetric induction was satisfactorily achieved using β-silylalkanoyl ketenes and the Evans-Sjogren ketene. C,C-Bis (trimethylsilyl)methylamine ketimines derived from enolizable dialkyl ketones cleanly led to the corresponding C(4) disubstituted β-lactams without deprotonation. Therefore, a general methodology for a convergent asymmetric synthesis of β-lactams in which C(4) exists as a quaternary carbon is provided.

Asymmetric 1,4-Addition of Higher Order Silylcuprates to Oppolzer's N-Enoyl Sultams

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