144701-23-5

Basic information

• Product Name: Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• CAS NO: 144701-23-5
• Molecular Formula: C20H21NO4S
• Molecular Weight: 371.457
• Mol File: 144701-23-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-(144701-23-5)
• EPA Substance Registry System: Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-(144701-23-5)

Safety Data

• Hazardous Substances Data: 144701-23-5(Hazardous Substances Data)

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 59-51-8 DL-methionine 
• 909114-66-5 9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate 

Downstream Products

• 71989-28-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine 
• 71989-28-1 Nα-fluorenyl-9-methoxycarbonyl-D-Met 
• 127869-51-6 human C-type natriuretic peptide 22 
• 63307-63-1 L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-L-proline amide 
• 124076-39-7 H-Tyr-D-Met-Gly-Phe-Hyp(Man)-NH₂ 

Relevant articles and documents

Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety

Novel chiral selectors based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin connecting quinine (QN) or quinidine (QD) moiety were synthesized and immobilized on silica gel. Their chromatographic performances were investigated by comparing to the 3,5-dimethyl phenylcarbamoylated β-cyclodextrin (β-CD) chiral stationary phase (CSP) and 9-O-(tert-butylcarbamoyl)-QN-based CSP (QN-AX). Fmoc-protected amino acids, chiral drug cloprostenol (which has been successfully employed in veterinary medicine), and neutral chiral analytes were evaluated on CSPs, and the results showed that the novel CSPs characterized as both enantioseparation capabilities of CD-based CSP and QN/QD-based CSPs have broader application range than β-CD-based CSP or QN/QD-based CSPs. It was found that QN/QD moieties play a dominant role in the overall enantioseparation process of Fmoc-amino acids accompanied by the synergistic effect of β-CD moiety, which lead to the different enantioseparation of β-CD-QN-based CSP and β-CD-QD-based CSP. Furthermore, new CSPs retain extraordinary enantioseparation of cyclodextrin-based CSP for some neutral analytes on normal phase and even exhibit better enantioseparation than the corresponding β-CD-based CSP for certain samples.

Useful reagents for introduction of Boc and Fmoc protective groups to amines: Boc-DMT and Fmoc-DMT

New amino-protecting reagents, Boc-DMT and Fmoc-DMT, were prepared, and found to be useful for the introduction of Boc and Fmoc groups into amines. Both the reagents can protect various amines including amino acids in good yield in aqueous media. Since the reagents are neither unstable nor irritating, they are practically useful. Georg Thieme Verlag Stuttgart.