144791-02-6

Basic information

• Product Name: 2-Cyclobuten-1-one, 2,3-bis(1,1-dimethylethoxy)-4-hydroxy-
• CAS NO: 144791-02-6
• Molecular Formula: C12H20O4
• Mol File: 144791-02-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Cyclobuten-1-one, 2,3-bis(1,1-dimethylethoxy)-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclobuten-1-one, 2,3-bis(1,1-dimethylethoxy)-4-hydroxy-(144791-02-6)
• EPA Substance Registry System: 2-Cyclobuten-1-one, 2,3-bis(1,1-dimethylethoxy)-4-hydroxy-(144791-02-6)

Safety Data

• Hazardous Substances Data: 144791-02-6(Hazardous Substances Data)

Upstream product

• 66478-66-8 3,4-di(tert-butoxy)cyclobut-3-ene-1,2-dione 

Downstream Products

• 31876-38-7 semisquaric acid 

Relevant articles and documents

A method for the stereoselective construction of 4-alkoxy-5-alkylideneecyclopentenones by the tandem ring expansion-functionalization of 1-alkynylcyclobutenols using a palladium-mercury cocatalytic system

1-(1-Alkynyl)-4-methoxy-4-methyl-2-cyclobutenols, prepared by nucleophilic functionalization of cyclobutenediones, were transformed with high stereoselectivity into 4-methoxy-4-methyl-5-alkylidenecyclopentenones. The action of stoichiometric Hg(OCOCF3)2 and then metathesis with NaCl produced 5-(1-(chloromercurio)alkylidene)-4-methoxy-4-methyl-2-cyclopentenones which were stereospecifically functionalized by palladium-mediated allylation and hydroxybutenylation. Treatment with Br2/DMSO led to stereospecific bromodemercuration. The 1-(1-alkynyl)-4-methoxy-4-methyl-2-cyclobutenols underwent efficient and very stereoselective tandem ring expansion-functionalizations in the presence of three different allylic chlorides and a catalyst system composed of 10% Hg(OCOCF3)2 and 10% PdCl2. All products can be obtained with a stereoselectivity greater than 99:1 at the exocyclic alkene.