1448311-40-7

Basic information

• Product Name: C₁₈H₁₈N₂O₃S
• Synonyms: C₁₈H₁₈N₂O₃S
• CAS NO: 1448311-40-7
• Molecular Weight: 342.419
• Mol File: 1448311-40-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈N₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈N₂O₃S(1448311-40-7)
• EPA Substance Registry System: C₁₈H₁₈N₂O₃S(1448311-40-7)

Safety Data

• Hazardous Substances Data: 1448311-40-7(Hazardous Substances Data)

Upstream product

• 4765-54-2 2-propyl-3H-quinazolin-4-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 107288-96-0 2-propyl-4-phenylquinazoline 

Relevant articles and documents

Palladium-Catalyzed Cross-Coupling of 4-Tosyloxyquinazolines with Organoindium Reagents: An Efficient Route to 4-Substituted Quinazolines

An efficient route to 4-substituted quinazolines by arylation or alkylation of quinazolinones under mild conditions is described. 4-Tosyloxyquinazolines were obtained through the reaction of quinazolinones and p-methylbenzenesulfonyl chloride in the presence of K2CO3. The cross-coupling reaction of 4-tosyloxyquinazolines with organoindium reagents, carried out in tetrahydrofuran, catalyzed by Pd2(dba)3/ (2-furyl)3P led to the formation of 4-functionalized quinazolines in good to excellent yields. Higher yields were obtained by the one-pot reaction of quinazolinone, p-methylbenzenesulfonyl chloride, Pd2(dba)3-/(2-furyl)3P, and organoindium reagent. These methods using organoindium compounds as coupling partners provided an efficient route to 4-(hetero)aryl/alkylquinazolines, especially 4-substituted quinazolines bearing a halogen scaffold.