4765-54-2

Basic information

• Product Name: 2-propylquinazolin-4(1H)-one
• CAS NO: 4765-54-2
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.2258
• Mol File: 4765-54-2.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 329.6°C at 760 mmHg
• Flash Point: 153.2°C
• Density: 1.18g/cm³
• Vapor Pressure: 0.000175mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 2-propylquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propylquinazolin-4(1H)-one(4765-54-2)
• EPA Substance Registry System: 2-propylquinazolin-4(1H)-one(4765-54-2)

Safety Data

• Hazardous Substances Data: 4765-54-2(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 3020-81-3 butylamidine hydrochloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 88-65-3 2-bromobenzoic-acid 
• 24964-76-9 triethyl orthobutyrate 
• 28144-70-9 anthranilic acid amide 
• 760-79-2 N,N-dimethylbutyramide 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 141-75-3 butyryl chloride 
• 187737-37-7 propene 
• 201230-82-2 carbon monoxide 
• 123-73-9 crotonaldehyde 
• 71-36-3 butan-1-ol 
• 102-82-9 tributyl-amine 

Downstream Products

• 84312-82-3 N-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-butyramide 
• 84312-84-5 2-(β-Ethylstyryl)-4(3H)-quinazolinone 
• 84312-83-4 N-[2-(Hydroxy-diphenyl-methyl)-phenyl]-butyramide 
• 107288-96-0 2-propyl-4-phenylquinazoline 
• 1448311-40-7 C₁₈H₁₈N₂O₃S 
• 137416-69-4 2-Propyl-3-[[2'-(N-trityltetrazol-5-yl) biphenyl-4-yl]methyl]-4(3H)-quinazolinone 
• 96547-01-2 5-(2-Propyl-quinazolin-4-yloxymethyl)-3-(4-p-tolyl-piperazin-1-ylmethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 96547-00-1 3-(4-Phenyl-piperazin-1-ylmethyl)-5-(2-propyl-quinazolin-4-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 96547-12-5 C₂₁H₂₃N₅O₃S 
• 96547-22-7 (4-Methoxy-phenyl)-[5-(2-propyl-quinazolin-4-yloxymethyl)-[1,3,4]thiadiazol-2-yl]-amine 
• 96547-13-6 C₂₀H₂₀ClN₅O₂S 
• 96546-97-3 3-Morpholin-4-ylmethyl-5-(2-propyl-quinazolin-4-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 96547-11-4 C₂₁H₂₃N₅O₂S 
• 96547-23-8 (4-Chloro-phenyl)-[5-(2-propyl-quinazolin-4-yloxymethyl)-[1,3,4]thiadiazol-2-yl]-amine 

Relevant articles and documents

Visible light induced tandem reactions: An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions

A facile tandem route has been developed for constructing quinazolinones from various aminobenzamides and in-situ generated aldehydes. Visible light was found to play a dual role: first oxidizes the alcohol to the aldehyde and then facilitates its cyclization with o-substituted aniline. Furthermore, alcohols are perfect alternatives to aldehydes because they are greener, more available, more economical, more stable, and less toxic than aldehydes. The first reaction step continuously provides material for the second step, which effectively reduces loss through volatilization, oxidation, and polymerization of the aldehyde, while avoiding its toxicity. A variety of quinazolinones can be prepared in the presence of visible light without any additional photocatalyst. The developed synthesis protocol proceeds with the merits of mild conditions, broad substrate scope, operational simplicity, and high atom efficiency, with an eco-energy source under metal-free, photocatalyst-free, and ambient conditions.

Effect of Fe(iii)-based MOFs on the catalytic efficiency of the tandem cyclooxidative reaction between 2-aminobenzamide and alcohols

The catalytic properties of metal-organic frameworks (MOFs) containing triangular Fe(iii) clusters in the promotion of organic syntheses and photocatalysis applications have been receiving substantial attention for decades. These clusters are appealing due to the strong Lewis acidity afforded by coordinatively unsaturated sites upon the removal of solvent from the framework. In this paper, triangular Fe(iii) cluster-based MOFs were shown to be highly efficient heterogeneous catalysts for the solvent-free one-pot condensation of 2-aminobenzamide and alcohols to form quinazolin-4-ones under microwave irradiation. The Fe-MOF catalysts ranging from microporous to mesoporous structures with a variety of geometrical pore structures were investigated. Because of the open accessible spaces for reactants and high density of active sites, MOF-907, built from trimer Fe clusters and a mixture of two linkers, was more effective than other Fe(iii)-MOFs. The catalyst can be used for a broad substrate scope and recycled several times without a significant drop-off in its activity.

Method for preparing quinazolinone from enol

The invention discloses a method for preparing a quinazolinone derivative from enol. According to the method, a relatively inexpensive ruthenium complex is used as a catalyst in a reaction to catalyzea microwave reaction of commercial and easily-available 2-aminobenzamide with enol for the preparation of quinazolinone. Compared with conventional synthesis methods for quinazolinone of the same kind, the method of the invention has the following advantages: no alkali is used in the reaction process; clean and non-toxic tetrahydrofuran is used as a reaction solvent; hydrogen is automatically transferred, and the atom economy of the reaction is high; and the by-product of the invention is only water.