144900-34-5

Basic information

• Product Name: 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate
• Synonyms: 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate;4-(2,2-Dichlorocyclopropyl)phenol acetate;Phenol 4-(2,2-dichlorocyclopropyl)-1-acetate;2-[4-(2,2-dichlorocyclopropyl)-1-hydroxycyclohexa-2,4-dien-1-yl]acetate;4-(2,2-dichlorocyclopropyl)phenyl acetate
• CAS NO: 144900-34-5
• Molecular Formula: C11H10Cl2O2
• Molecular Weight: 245.1019
• Mol File: 144900-34-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 340.8±42.0 °C(Predicted)
• Appearance: white like or light brown crystalline powder
• Density: 1.35
• Vapor Pressure: 0.12Pa at 25℃
• Storage Temp.: 2-8°C
• Water Solubility: 35.72mg/L at 25℃
• CAS DataBase Reference: 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate(144900-34-5)
• EPA Substance Registry System: 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate(144900-34-5)

Safety Data

• Hazardous Substances Data: 144900-34-5(Hazardous Substances Data)

Usage

Description

4-(2,2-Dichlorocyclopropyl)phenol 1-acetate is a nearly white crystalline powder with specific chemical properties that make it a valuable compound in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
4-(2,2-Dichlorocyclopropyl)phenol 1-acetate is used as an intermediate for the synthesis of Ciprofibrate, which is a hypolipemic agent. Ciprofibrate is structurally related to Clofibrate and is utilized as an antilipemic, helping to regulate lipid levels in the body and potentially reducing the risk of cardiovascular diseases.
Used in Chemical Synthesis:
Due to its unique chemical structure, 4-(2,2-Dichlorocyclopropyl)phenol 1-acetate can be employed as a key intermediate in the synthesis of other pharmaceutical compounds or chemical products. Its versatility in chemical reactions allows for the creation of a wide range of applications in various industries.
Used in Research and Development:
The compound's specific properties make it an interesting subject for research and development in the fields of chemistry, pharmacology, and materials science. It can be used to study the effects of its structure on various biological systems and to develop new methods for its synthesis and application.

Upstream product

• 40641-93-8 1-(4-acetylphenyl)-2,2-dichlorocyclopropane 

Relevant articles and documents

Synthetic method of 4-(2,2-dichloro cyclopropyl)phenol acetate

The invention discloses a synthetic method of 4-(2,2-dichloro cyclopropyl)phenol acetate. The synthetic method comprises the following steps: taking 2,2-dichloro cyclopropyl benzene as a starting rawmaterial and carrying out electrophilic substitution reaction and baeyer-villiger oxidation reaction to synthesize the 4-(2,2-dichloro cyclopropyl)phenol acetate. According to the preparation method disclosed by the invention, an iodine element-containing co-catalyst is added into the electrophilic substitution reaction to reduce the temperature of the electrophilic substitution reaction, so thatthe selectivity of the electrophilic substitution reaction is improved; the content of an ortho-isomer is reduced within 0.3 percent by adopting relatively-inexpensive acetyl chloride as an electrophilic reagent; the activity of oxidation reaction is improved by adding an iron salt catalyst in the baeyer-villiger oxidation reaction, so that the reaction can be successfully carried out under the condition of taking acetic anhydride as an oxidizing medium, the yield of oxidation reaction is improved and potential safety hazards of a post-treatment process are reduced.