1449517-06-9Relevant articles and documents
The sequential reactions of tetrazoles with bromoalkynes for the synthesis of (Z)-N-(2-bromo-1-vinyl)-N-arylcyanamides and 2-arylindoles
Zhang, Jiajun,Meng, Ling-Guo,Li, Pinhua,Wang, Lei
, p. 6807 - 6812 (2013/05/23)
2-Arylindoles were prepared by a sequential reaction of Ag-catalyzed α-addition-Pd-catalyzed C-H bond functionalization of tetrazoles with bromoalkynes. A stereocontrolled Ag-catalyzed α-addition reaction of tetrazoles with bromoalkynes underwent smoothly to generate (Z)-N-(2-bromo-1- vinyl)-N-arylcyanamides, which were subsequently converted into 2-arylindoles through an intramolecular cyclization by Pd-catalyzed direct C-H bond functionalizations.