1452108-88-1

Basic information

• Product Name: sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• Synonyms: sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• CAS NO: 1452108-88-1
• Molecular Weight: 239.249
• Mol File: 1452108-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate(1452108-88-1)
• EPA Substance Registry System: sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate(1452108-88-1)

Safety Data

• Hazardous Substances Data: 1452108-88-1(Hazardous Substances Data)

Upstream product

• 88928-69-2 1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester 
• 6197-39-3 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrochloride 
• 63-75-2 arecoline 
• 300-08-3 arecoline hydrobromide 

Relevant articles and documents

N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive α-glucosidase inhibitors

Abstract The enzyme α-glucosidase has attracted interest owing to its involvement in the digestive process of carbohydrate, its role in intracellular glycoprotein trafficking, tumorigenesis and viral infection. In this study, several members of a new family of N-heteroarylmethyl substituted azasugars were synthesized and evaluated as α-glucosidase inhibitors. We systematically investigated the effect of different N-substituents as well as the role of hydroxyl and carboxylate moieties on the piperidine ring. The compounds N-heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid emerged as potent α-glucosidase inhibitors. Unlike Acarbose and other clinically relevant α-glucosidase inhibitors, these compounds act through a reversible uncompetitive mechanism of inhibition which make them attractive candidates for drug development.