145315-38-4

Basic information

• Product Name: H-Arg^ω,ω'(Boc)2-OH
• Synonyms: H-Arg^ω,ω'(Boc)2-OH
• CAS NO: 145315-38-4
• Molecular Weight: 374.437
• Mol File: 145315-38-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: H-Arg^ω,ω'(Boc)2-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-Arg^ω,ω'(Boc)2-OH(145315-38-4)
• EPA Substance Registry System: H-Arg^ω,ω'(Boc)2-OH(145315-38-4)

Safety Data

• Hazardous Substances Data: 145315-38-4(Hazardous Substances Data)

Upstream product

• 70-26-8 L-ornithine 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 107819-90-9 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 
• 83585-01-7 Z-Arg^ω,ω'(Boc)2-OH 

Downstream Products

• 83585-01-7 Cbz-Arg(Boc)2-OH 
• 1261082-28-3 benzyl (1S)-1-[({(1S,2R)-1-benzyl-2-hydroxy-3-[({4-[(E)-(hydroxyimino)methyl]phenyl}sulfonyl)(isobutyl)amino]propyl}amino)carbonyl]-4-[((Z)-[(tert-butoxycarbonyl)amino]{[(Z)-tert-butoxycarbonyl]imino}methyl)amino]butylcarbamate 
• 143824-77-5 Fmoc-Arg^ω,ω'(Boc)2-OH 
• 143824-77-5 N-α-(9-fluorenylmethyloxycarbonyl)-N-ω′,N-ω″-bis-tert-butyloxycarbonyl-L-argine 

Relevant articles and documents

Miraziridine A: Natures blueprint towards protease class-spanning inhibitors

The natural product miraziridine A isolated from the marine sponge Theonella aff. mirabilis unifies within one molecule three structurally privileged elements: (i) (2R,3R)-aziridine-2,3-dicarboxylic acid, (ii) (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine), and (iii) (E)-(S)-4-amino-7-guanidino-hept-2-enoic acid (vinylogous arginine). The alignment of them realized in the tetrapetide allows for a simultaneous inhibition of the proteolytic activity of trypsin-like serine proteases, papain-like cysteine proteases, and pepsin-like aspartyl proteases. Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors.

Total synthesis of cyclotheonamide B, a facile route towards analogues

A flexible, convergent synthesis of cyclotheonamide B (1b) was developed, starting from the constituent amino acids, using conventional benzyl-, t-butyl- and allyl-based protecting groups. By modification of the key intermediates, this approach allows the preparation of cyclotheonamide analogues.