145678-87-1

Basic information

• Product Name: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE
• Synonyms: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE;(+)-(3s,4s)-3,4-diMethyl-4-(3-hydroxyphenyl)piperidine;(-)-3-[(3S,4S)-3,4-Dimethylpiperidin-4-yl]phenol
• CAS NO: 145678-87-1
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol File: 145678-87-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 335.464 °C at 760 mmHg
• Flash Point: 115.716 °C
• Appearance: /
• Density: 1.009 g/cm³
• CAS DataBase Reference: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(145678-87-1)
• EPA Substance Registry System: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(145678-87-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 145678-87-1(Hazardous Substances Data)

Usage

Description

(+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE is a complex organic compound with a unique molecular structure, characterized by its stereochemistry and functional groups. It is a chiral molecule with specific stereodescriptors (3R,4S), indicating the spatial arrangement of its atoms. The presence of a 3-hydroxyphenyl group attached to the piperidine ring suggests potential biological activity and applications in various fields.

Uses

Used in Pharmaceutical Industry:
(+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Opioid Drug Preparation:
(+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE is used as a crucial component in the preparation of opioid drugs, such as Alvimopan. Its incorporation into the drug's structure contributes to the drug's efficacy and pharmacological properties, making it an essential part of the drug's synthesis process.

Upstream product

• 149541-62-8 cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester 
• 131738-73-3 3-(isopropyloxy)phenylbromide 
• 149541-62-8 C₁₉H₂₉NO₄ 
• 145340-44-9 1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol 
• 149541-62-8 Carbonic acid ethyl ester (3R,4S)-4-(3-isopropoxy-phenyl)-1,3-dimethyl-piperidin-4-yl ester 
• 223424-24-6 (3S,4S)-4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine 
• 444904-02-3 (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine 
• 4629-80-5 1,3-dimethyl-4-piperidinone 

Downstream Products

• 156130-44-8 2‐((S)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 156130-44-8 2‐((R)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 120938-72-9 LY 255265 
• 120938-72-9 LY 255609 
• 441003-84-5 (R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 361444-66-8 (3R)-7-hydroxy-N-((1S)-1-{[(3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide 
• 441003-83-4 3-[1-(2S-amino-3-methylbutyl)-3S,4S-dimethyl-4-piperidinyl]phenol 

Relevant articles and documents

Synthesis and characterization of all possible diastereoisomers of alvimopan

Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.

1,3,4-Trisubstituted-4-arylpiperidines and their preparation

Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methyl