156130-44-8Relevant articles and documents
Synthesis and characterization of all possible diastereoisomers of alvimopan
Reddy, Beeravalli Ramalinga,Dubey, Manoj Kumar,Ramana Reddy, Ch. Venkata,Bandichhor, Rakeshwar
, p. 963 - 972 (2018/05/28)
Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.
A Love [...] synthetic method
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Paragraph 0050; 0051, (2017/10/13)
The invention relates to a synthesis method of alvimopan. The method comprises the steps of taking the compound A of an acetyl protection piperidine fragment as a raw material and reacting with (S)-ethyl-2-(2-benzyl-3-methyl sulfonoxy alanyl)-acetic acid, then performing one-step basic hydrolysis to prepare the alvimopan. In the technical solution, the synthesis method has the advantages of mild production conditions, simple production process, less side reactions, high product yield, high purity and the like, and is suitable for industrialized large-scale production.
AN IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXY PHENYL)-3(R), 4-DIMETHYL-1 -PIPERIDINYL]METHYL]-1 -OXO-3-PHENYLPROPYL] AMINO]ACETIC ACID DIHYDRATE
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, (2017/10/11)
The present invention relates to an improved process for the preparation of [[2(S)-[[4(R)- (3 -hydroxypheny l)-3 (R),4-dimethyl- 1 -piperidinyl] methyl] - 1 -oxo- 3 -phenylpropyl] amino] acetic acid dihydrate, represented by the following structural formula: