1458715-46-2

Basic information

• Product Name: 6-fluoro-2-(4-(2-(4-fluorophenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole
• Synonyms: 6-fluoro-2-(4-(2-(4-fluorophenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole
• CAS NO: 1458715-46-2
• Molecular Weight: 402.467
• Mol File: 1458715-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-(4-(2-(4-fluorophenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(4-(2-(4-fluorophenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole(1458715-46-2)
• EPA Substance Registry System: 6-fluoro-2-(4-(2-(4-fluorophenyl)-5-methyl-1H-pyrrol-1-yl)phenyl)benzo[d]thiazole(1458715-46-2)

Safety Data

• Hazardous Substances Data: 1458715-46-2(Hazardous Substances Data)

Upstream product

• 347-81-9 4-nitro-N-(4-fluorophenyl)benzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 371-40-4 4-fluoroaniline 
• 459-57-4 4-fluorobenzaldehyde 
• 123183-95-9 1-(4-fluoro-phenyl)-pentane-1,4-dione 
• 328087-15-6 4-(6-fluorobenzo[d]thiazol-2-yl)benzenamine 
• 343975-46-2 6-fluoro-2-(4-nitrophenyl)benzo[d]thiazole 
• 167565-72-2 N-(4-fluorophenyl)-4-nitro-1-benzenecarbothioamide 

Relevant articles and documents

Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells

By applying a methodology, a series of benzothiazole-pyrrole based conjugates (4a-r) were synthesized and evaluated for their antiproliferative activity. Compounds such as 4a, 4c, 4e, 4g-j, 4m, 4n, 4o and 4r exhibited significant cytotoxic effect in the MCF-7 cell line. Cell cycle effects were examined for these conjugates at 2 μM as well as 4 μM concentrations and FACS analysis show an increase of G2/M phase cells with concomitant decrease of G1 phase cells thereby indicating G2/M cell cycle arrest by them. Interestingly 4o and 4r are effective in causing apoptosis in MCF-7 cells. Moreover, 4o showed down regulation of oncogenic expression of Ras and its downstream effector molecules such as MEK1, ERK1/2, p38 MAPK and VEGF. The apoptotic aspect of this conjugate is further evidenced by increased expression of caspase-9 in MCF-7 cells. Hence these small molecules have the potential to control both the cell proliferation as well as the invasion process in the highly malignant breast cancers.